{"id":"W2118598606","doi":"10.1074/jbc.c000106200","title":"Suppressor of Cytokine Signaling-1 Inhibits VAV Function through Protein Degradation","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":166,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"Medical Research Council","keywords":"Suppressor of cytokine signaling 1; Ubiquitin ligase; Suppressor of cytokine signalling; Ubiquitin; Proto-oncogene tyrosine-protein kinase Src; Cytokine; SOCS6; SOCS3; SOCS2; SOCS5; SH2 domain; Janus kinase; Cell biology; Signal transduction; Guanine nucleotide exchange factor; Biology; Chemistry; Cancer research; STAT3; Suppressor; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000190069,0.0001235562,0.0003409515,0.00002480503,0.00003877876,0.000009450151,0.00007561382,0.0001676097,0.00473436],"category_scores_gemma":[0.0002109336,0.00008113484,0.0002306365,0.0001370507,0.00007079689,0.0001010486,0.00001196283,0.0003667092,0.000008675867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004332566,"about_ca_system_score_gemma":0.00006132758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005545597,"about_ca_topic_score_gemma":9.216974e-8,"domain_scores_codex":[0.9988647,0.00002810903,0.0006209637,0.0001301858,0.0002219736,0.0001340594],"domain_scores_gemma":[0.9990973,0.00005435831,0.0003704704,0.0001161778,0.000277016,0.00008471814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001066747,0.0003246889,0.000307679,0.00006157008,0.00006408157,0.00002020923,0.00002661693,0.0000330595,0.9961135,0.00001011856,0.0003854599,0.001586304],"study_design_scores_gemma":[0.0009565612,0.0009553246,0.0005754746,0.0003044676,0.00007071707,0.0004197165,0.00005519626,0.00002866282,0.9882613,0.0002409116,0.008051313,0.0000803341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957457,0.0002029816,0.0005245738,0.0003547783,0.00004901286,0.0001044809,0.00001595291,0.00001649208,0.002985989],"genre_scores_gemma":[0.9977114,0.00004262865,0.001082882,0.00008892598,0.0004517928,0.000003598259,0.00003119289,0.000008098715,0.0005794779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007852144,"threshold_uncertainty_score":0.9961755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03762776810750523,"score_gpt":0.2759634940558714,"score_spread":0.2383357259483662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}