{"id":"W2118598606","doi":"10.1074/jbc.c000106200","title":"Suppressor of Cytokine Signaling-1 Inhibits VAV Function through Protein Degradation","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":166,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"Medical Research Council","keywords":"Suppressor of cytokine signaling 1; Ubiquitin ligase; Suppressor of cytokine signalling; Ubiquitin; Proto-oncogene tyrosine-protein kinase Src; Cytokine; SOCS6; SOCS3; SOCS2; SOCS5; SH2 domain; Janus kinase; Cell biology; Signal transduction; Guanine nucleotide exchange factor; Biology; Chemistry; Cancer research; STAT3; Suppressor; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001132899,0.0002990151,0.0002408577,0.0001721659,0.0001026976,0.0003060814,0.0001591143,0.0001413342,0.001152562],"category_scores_gemma":[0.0001504159,0.00007564975,0.0001528183,0.000100208,0.0001707488,0.0001055907,0.0001135045,0.0003474158,0.000398866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003088164,"about_ca_system_score_gemma":0.0001475306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002326671,"about_ca_topic_score_gemma":0.0004017762,"domain_scores_codex":[0.9998763,0.00002387872,0.000008910481,0.00001927127,0.00002488865,0.00004675049],"domain_scores_gemma":[0.9998921,0.0000236595,0.00003078549,0.00001239328,0.000009207953,0.00003184996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002000141,0.00006563155,0.0003205584,0.00003030268,0.00000752162,0.00003639124,0.000007561573,0.0001342722,0.9959376,0.0002770712,0.0001310843,0.002851942],"study_design_scores_gemma":[0.0000390733,0.000660705,0.003927448,0.000004066716,0.00001081021,0.0002787668,0.00001161987,0.001773733,0.9900413,0.00008102797,0.003168887,0.000002470232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949383,0.002500156,0.0007910317,0.00007272766,0.00003694647,0.00001137697,0.0001651993,0.00007867703,0.001405643],"genre_scores_gemma":[0.9976509,0.0005265697,0.0003485416,0.00002155297,0.000008841809,0.000009898185,0.0003152488,0.00000841997,0.001110051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001152562,"threshold_uncertainty_score":0.003855765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03762776810750523,"score_gpt":0.2759634940558714,"score_spread":0.2383357259483662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}