{"id":"W2118612419","doi":"10.1073/pnas.0800658105","title":"Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of California, Irvine; School of Medicine, New York University; National Institutes of Health; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; York University","keywords":"Huntingtin; Gene silencing; Argonaute; Biology; Colocalization; Huntington's disease; Huntingtin Protein; Mutant; Gene; RNA; Gene knockdown; Cell biology; RNA-induced silencing complex; Molecular biology; RNA interference; Genetics; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004383901,0.0001280866,0.0001669365,0.000119988,0.0004817388,0.00003985373,0.0004479431,0.00003807075,0.000003049264],"category_scores_gemma":[0.005729737,0.0000856434,0.00003966599,0.0007196986,0.0007289595,0.0004538722,0.0001570444,0.0001074045,0.000001552501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004881607,"about_ca_system_score_gemma":0.00008376277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004622443,"about_ca_topic_score_gemma":8.035931e-8,"domain_scores_codex":[0.9977218,0.00002085733,0.0002614057,0.0004052659,0.001369646,0.0002210341],"domain_scores_gemma":[0.9988248,0.0002795034,0.0004507401,0.00001089503,0.0003612924,0.0000727857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003566531,0.00003850904,0.03032338,0.0000262363,0.000005449638,2.408491e-8,0.0002690048,0.0001514674,0.9647295,0.004188144,0.0002175947,0.00001504301],"study_design_scores_gemma":[0.0001857391,0.00004597666,0.1717208,0.00006468939,0.00001084548,0.000001236515,0.00004462577,0.0001586628,0.8225901,0.005056724,0.00003875923,0.00008176864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933394,0.00007472361,0.000004580487,0.005524915,0.00001354575,0.000449759,0.00005867655,0.00002062903,0.0005138332],"genre_scores_gemma":[0.9976686,0.00003861986,0.0007938057,0.001236559,0.00003789604,0.00004571529,1.305228e-7,0.000006214978,0.0001724358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1421394,"threshold_uncertainty_score":0.6859444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03775816799115422,"score_gpt":0.2733637947841571,"score_spread":0.2356056267930029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}