{"id":"W2118612771","doi":"10.1128/jvi.77.4.2530-2538.2003","title":"Identification of a Receptor-Binding Domain of the Spike Glycoprotein of Human Coronavirus HCoV-229E","year":2003,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":198,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"National Cancer Institute; Canadian Institutes of Health Research; U.S. Public Health Service; National Institutes of Health","keywords":"Biology; Coronavirus; Glycoprotein; Virology; Betacoronavirus; Identification (biology); Spike (software development); Receptor; Spike Protein; Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Computational biology; Genetics; Outbreak","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008575555,0.0002600042,0.0003160576,0.0001758086,0.0001908761,0.0003055671,0.0001878673,0.0005109162,0.0008766977],"category_scores_gemma":[0.0002249539,0.0002047139,0.0005479556,0.0001084737,0.0001672008,0.0002105218,0.0002179597,0.0003734507,0.0008493554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004716981,"about_ca_system_score_gemma":0.0003234769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001888079,"about_ca_topic_score_gemma":0.002489739,"domain_scores_codex":[0.9999071,0.00001340358,0.000007419896,0.00001496338,0.00003168285,0.00002540911],"domain_scores_gemma":[0.9999154,0.00001357871,0.00001496122,0.00000983823,0.00001987019,0.00002631908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005292013,0.00001558897,0.000810805,0.00002659631,0.000005342434,0.0001697352,0.00001715417,0.00004417979,0.9980465,0.0001053086,0.00004976314,0.0006560909],"study_design_scores_gemma":[0.00005890118,0.0005908016,0.06623317,0.00002732769,0.00005178778,0.004487794,0.0002403509,0.005396272,0.9136003,0.0002279843,0.009059305,0.00002588267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996998,0.000573948,0.00124107,0.00009384023,0.00001501961,0.00002451305,0.000267652,0.00001532817,0.0007707233],"genre_scores_gemma":[0.9913825,0.0007024489,0.004260561,0.0001726291,0.00001676881,0.00002235269,0.00185931,0.00001218098,0.001571234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001888079,"threshold_uncertainty_score":0.003754199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02247682790981417,"score_gpt":0.325484525364366,"score_spread":0.3030076974545518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}