{"id":"W2118613141","doi":"10.2215/cjn.01360210","title":"Prospects for mTOR Inhibitor Use in Patients with Polycystic Kidney Disease and Hamartomatous Diseases","year":2010,"lang":"en","type":"review","venue":"Clinical Journal of the American Society of Nephrology","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Medicine; PI3K/AKT/mTOR pathway; mTORC2; mTORC1; Polycystic kidney disease; Autosomal dominant polycystic kidney disease; Pharmacology; Everolimus; Cancer research; Kidney disease; Internal medicine; Kidney; Endocrinology; Signal transduction; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000220585,0.0003140308,0.001502758,0.00003768441,0.0000546107,0.00001790943,0.0004340606,0.0002261271,0.00000218323],"category_scores_gemma":[0.0009774995,0.0001876358,0.00124079,0.0001309219,0.001654604,0.000006681968,0.0002071648,0.0003886621,2.968019e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001565594,"about_ca_system_score_gemma":0.001235065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003628616,"about_ca_topic_score_gemma":0.000002114804,"domain_scores_codex":[0.9978555,0.0002900945,0.00101677,0.0003630223,0.0001946444,0.0002799747],"domain_scores_gemma":[0.9964339,0.0003271135,0.001990587,0.0004529607,0.0002194284,0.0005759975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01807601,0.00497932,0.4158278,0.008729102,0.004302643,0.00002288376,0.00005035654,0.000004386521,0.0003101851,0.000007527733,0.2926818,0.255008],"study_design_scores_gemma":[0.002549232,0.002690885,0.1671615,0.001220889,0.002149384,0.00001808686,0.0000129637,0.000002881604,0.00000338403,0.00004689221,0.8238481,0.0002957687],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.4701589,0.526991,0.00005601385,0.0004560089,0.0003716921,0.001158079,0.0008032326,0.000004088938,8.992328e-7],"genre_scores_gemma":[0.01802255,0.9702632,0.002393459,0.008033668,0.000981119,0.0000470392,0.0001185901,0.00008621706,0.00005413156],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5311664,"threshold_uncertainty_score":0.7651567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01887291035580097,"score_gpt":0.3147898797725243,"score_spread":0.2959169694167233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}