{"id":"W2118613141","doi":"10.2215/cjn.01360210","title":"Prospects for mTOR Inhibitor Use in Patients with Polycystic Kidney Disease and Hamartomatous Diseases","year":2010,"lang":"en","type":"review","venue":"Clinical Journal of the American Society of Nephrology","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Medicine; PI3K/AKT/mTOR pathway; mTORC2; mTORC1; Polycystic kidney disease; Autosomal dominant polycystic kidney disease; Pharmacology; Everolimus; Cancer research; Kidney disease; Internal medicine; Kidney; Endocrinology; Signal transduction; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00121139,0.0004374182,0.001256264,0.0005349169,0.0003410192,0.0009675504,0.0005181404,0.001412185,0.008087371],"category_scores_gemma":[0.001681599,0.0000932725,0.001385794,0.0004984449,0.0002991288,0.0008235407,0.0004138055,0.001669193,0.002070701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005041329,"about_ca_system_score_gemma":0.001224561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005373327,"about_ca_topic_score_gemma":0.001155174,"domain_scores_codex":[0.9996123,0.0001439712,0.00004675696,0.0000657381,0.00007451922,0.00005687416],"domain_scores_gemma":[0.9987304,0.0004616265,0.0002105171,0.00003035504,0.0001835634,0.0003836268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004635436,0.0009826038,0.015363,0.002118506,0.0003965439,0.001159483,0.00007457629,0.0004009052,0.004360243,0.003179863,0.04167541,0.9256535],"study_design_scores_gemma":[0.005180665,0.01115344,0.08255316,0.007149396,0.003129577,0.01190633,0.0006114499,0.001905694,0.004857339,0.01343021,0.8579596,0.0001631573],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03340669,0.8796175,0.003914152,0.05805305,0.002701591,0.0001513758,0.0009232673,0.0002171494,0.02101521],"genre_scores_gemma":[0.2596447,0.6407171,0.01618702,0.05027977,0.01497505,0.0007395179,0.003421661,0.0001164784,0.01391882],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008087371,"threshold_uncertainty_score":0.02705497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01887291035580097,"score_gpt":0.3147898797725243,"score_spread":0.2959169694167233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}