{"id":"W2118629005","doi":"10.1371/journal.pbio.1000287","title":"A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint","year":2010,"lang":"en","type":"article","venue":"PLoS Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":229,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; Ontario Genomics; National Institutes of Health; Deutsche Nierenstiftung; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw; Deutsche Forschungsgemeinschaft; National Institute of General Medical Sciences; Ontario Genomics Institute; Genome Canada; American Cancer Society","keywords":"G2-M DNA damage checkpoint; Checkpoint Kinase 2; CHEK1; Biology; Cell cycle checkpoint; Cell biology; DNA damage; Cyclin-dependent kinase 1; PLK1; DNA repair; Cell cycle; Polo-like kinase; Mitosis; Genetics; DNA; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003129652,0.000230411,0.0002241887,0.00003337852,0.0001572709,0.00003095968,0.0002848084,0.0003374863,0.00005914552],"category_scores_gemma":[0.0003630095,0.000172851,0.00006799494,0.0001257525,0.0001602506,0.0000049717,0.0003220932,0.0002472262,0.0000543784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001134009,"about_ca_system_score_gemma":0.00004811298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002993559,"about_ca_topic_score_gemma":0.0002093634,"domain_scores_codex":[0.9985929,0.0001235254,0.0002276927,0.0005435374,0.00007409662,0.0004382589],"domain_scores_gemma":[0.9990232,0.00006846692,0.0001094491,0.0005798985,0.00007913687,0.0001398344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001081314,0.00004690298,0.001565892,0.00000975333,0.00007136994,0.000002120077,0.00008764569,0.00001200895,0.9952295,0.001540656,0.0005436318,0.0007823329],"study_design_scores_gemma":[0.0005123723,0.0005687665,0.007686278,0.00001399811,0.0000368236,0.00002487972,0.00006961677,0.0003051178,0.9699836,0.002212036,0.01829132,0.0002952372],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962404,0.0001721119,0.0003130464,0.00107494,0.0005499495,0.0005002246,0.00001347489,0.00004040035,0.001095503],"genre_scores_gemma":[0.9960905,0.00004467169,0.001555599,0.001153146,0.0006597824,0.00007349293,0.00008198126,0.00003445273,0.0003064047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02524601,"threshold_uncertainty_score":0.7048659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008440977282537215,"score_gpt":0.224623284709621,"score_spread":0.2161823074270838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}