{"id":"W2118629005","doi":"10.1371/journal.pbio.1000287","title":"A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint","year":2010,"lang":"en","type":"article","venue":"PLoS Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":229,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; Ontario Genomics; National Institutes of Health; Deutsche Nierenstiftung; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw; Deutsche Forschungsgemeinschaft; National Institute of General Medical Sciences; Ontario Genomics Institute; Genome Canada; American Cancer Society","keywords":"G2-M DNA damage checkpoint; Checkpoint Kinase 2; CHEK1; Biology; Cell cycle checkpoint; Cell biology; DNA damage; Cyclin-dependent kinase 1; PLK1; DNA repair; Cell cycle; Polo-like kinase; Mitosis; Genetics; DNA; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006939811,0.0004274099,0.0001748085,0.0001570728,0.0002303962,0.0002713889,0.0002272593,0.0001662303,0.001747864],"category_scores_gemma":[0.00009861178,0.0001734899,0.0001687452,0.0001049521,0.000146303,0.0003180732,0.0002260924,0.0002772131,0.0004561461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004910486,"about_ca_system_score_gemma":0.0002619557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005599353,"about_ca_topic_score_gemma":0.0008382666,"domain_scores_codex":[0.9999515,0.000004530947,0.000002063661,0.00001718253,0.0000126673,0.00001213176],"domain_scores_gemma":[0.9999559,0.000005599924,0.00001849614,0.000003928584,0.000004275758,0.00001178545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001234479,0.00002632737,0.001112334,0.00004522929,0.000008317285,0.00008495557,0.000008959265,0.00121919,0.9920415,0.0005802443,0.00005511887,0.004694328],"study_design_scores_gemma":[0.0000425074,0.0003034475,0.02100863,0.00001008312,0.00004062186,0.000601591,0.00003716313,0.01967025,0.9530662,0.0007037498,0.004504514,0.00001126338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864371,0.0007733194,0.01070902,0.00006284255,0.00001629361,0.0000243476,0.0001446807,0.0001729592,0.001659327],"genre_scores_gemma":[0.9944927,0.0003817605,0.00311512,0.00001657154,0.000003827934,0.00001682154,0.0002639762,0.00001274126,0.001696578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001747864,"threshold_uncertainty_score":0.005847216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008440977282537215,"score_gpt":0.224623284709621,"score_spread":0.2161823074270838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}