{"id":"W2118645534","doi":"10.1158/0008-5472.can-13-1346","title":"Taccalonolide Binding to Tubulin Imparts Microtubule Stability and Potent <i>In Vivo</i> Activity","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"Phytochemical Studies and Bioactivities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Dental and Craniofacial Research; Canadian Institutes of Health Research; National Cancer Institute; U.S. Food and Drug Administration","keywords":"Tubulin; Microtubule; In vivo; Cell biology; Chemistry; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000101682,0.0003792218,0.0002383787,0.0002555173,0.0001615684,0.0002125543,0.0001989713,0.0002274954,0.0007029635],"category_scores_gemma":[0.00009183647,0.00009297999,0.0001839248,0.0001520036,0.0001282969,0.0001077344,0.0000753529,0.0005129647,0.0002147978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000312037,"about_ca_system_score_gemma":0.0001796992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001248686,"about_ca_topic_score_gemma":0.002861813,"domain_scores_codex":[0.9999104,0.00001488762,0.00000665326,0.00001301919,0.00002255537,0.00003255428],"domain_scores_gemma":[0.9999207,0.000009203493,0.00002134044,0.00001031855,0.00001585714,0.0000225624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002943937,0.0001091978,0.000116483,0.00004039197,0.000008240191,0.00003853357,0.000009142868,0.000124159,0.9953805,0.00007620144,0.0002307087,0.003572059],"study_design_scores_gemma":[0.00005120254,0.001758784,0.001874725,0.000004173866,0.00002399755,0.000161353,0.000007616475,0.0004091208,0.9925505,0.00001494747,0.003139746,0.000003787258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889925,0.002398051,0.002556437,0.0001587923,0.00005348672,0.00007159486,0.0006136698,0.0002304706,0.004924962],"genre_scores_gemma":[0.9938531,0.001214827,0.001331992,0.00009194732,0.00002273322,0.00005718756,0.0009422663,0.00002683222,0.002459151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001248686,"threshold_uncertainty_score":0.002482772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0459998472877606,"score_gpt":0.3490478255572117,"score_spread":0.3030479782694511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}