{"id":"W2118656013","doi":"10.1016/s1097-2765(04)00062-0","title":"PML Is a Direct p53 Target that Modulates p53 Effector Functions","year":2004,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":300,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"National Cancer Institute; National Institute on Aging","keywords":"Biology; Effector; Promyelocytic leukemia protein; Cell biology; Transcription factor; Suppressor; Mediator; Cell cycle checkpoint; Gene; Transcription (linguistics); Tumor suppressor gene; DNA damage; Cancer research; Reporter gene; Cell cycle; Nuclear protein; DNA; Gene expression; Genetics; Carcinogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000133145,0.0003352493,0.0002354769,0.00006304684,0.0001551445,0.00006526006,0.0003160217,0.0002854561,0.0001297567],"category_scores_gemma":[0.00003484831,0.0003211985,0.0002733001,0.0001750397,0.0001060821,0.000007414353,0.0001422135,0.0001724424,0.0003126899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000454821,"about_ca_system_score_gemma":0.0001461578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003906042,"about_ca_topic_score_gemma":0.000002574902,"domain_scores_codex":[0.9983431,0.00006875881,0.0002076946,0.000669451,0.0002577913,0.0004531823],"domain_scores_gemma":[0.998998,0.000009982995,0.00009345028,0.0006541563,0.00008667883,0.0001577525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003777545,0.0001287369,0.0008684102,0.00008647833,0.00009069292,0.00005322838,0.00006480422,0.001539269,0.994264,0.00001871378,0.002468154,0.0003797417],"study_design_scores_gemma":[0.0008241087,0.0002430448,0.00009261355,0.00001963368,0.00006002376,0.00001660258,0.00003365809,0.00004071511,0.9051837,0.0002241363,0.092887,0.000374771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9320346,0.007818199,0.02933147,0.0002071775,0.0003753873,0.0003413955,0.00006081643,0.00007574794,0.02975519],"genre_scores_gemma":[0.9923815,0.0002273565,0.001895796,0.0008312975,0.0001702744,0.00006462565,0.000364047,0.00007576617,0.003989304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09041885,"threshold_uncertainty_score":0.999924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004829362974195094,"score_gpt":0.2031551369829442,"score_spread":0.1983257740087491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}