{"id":"W2118693119","doi":"10.1177/0091270006292163","title":"Drug‐Disease Interactions: Losartan Effect Is Not Downregulated by Rheumatoid Arthritis","year":2006,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Losartan; Rheumatoid arthritis; Active metabolite; Pharmacology; Metabolite; Medicine; Arthritis; Inflammation; Pharmacokinetics; Internal medicine; Endocrinology; Angiotensin II; Chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003895806,0.0002151463,0.0009377617,0.0001865748,0.0002470957,0.0003244813,0.0001243608,0.0002666583,0.006138461],"category_scores_gemma":[0.001146167,0.00008272128,0.000261616,0.0001789645,0.0002524001,0.0002082205,0.0001976656,0.0005250301,0.0008707374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002472333,"about_ca_system_score_gemma":0.0002616285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002786482,"about_ca_topic_score_gemma":0.0006538738,"domain_scores_codex":[0.9994512,0.0001782866,0.00005214122,0.0000802088,0.0001649096,0.00007322992],"domain_scores_gemma":[0.9994758,0.0001675352,0.00009906058,0.00005617414,0.00006225079,0.0001392959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03176448,0.001963347,0.04158027,0.0009370175,0.001003167,0.002842638,0.0001664879,0.0003377845,0.7548859,0.0006512377,0.004144741,0.1597228],"study_design_scores_gemma":[0.00281918,0.0378335,0.6193954,0.00009098524,0.001897061,0.01258714,0.000151406,0.002616372,0.2616676,0.001430386,0.05945481,0.00005620018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838302,0.005615063,0.0009231265,0.0005891906,0.0001503945,0.00007009743,0.0004062638,0.0001113799,0.008304356],"genre_scores_gemma":[0.9970982,0.0006123918,0.0002683329,0.0001977801,0.00005847232,0.000020916,0.0002098666,0.000008879032,0.001525098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006138461,"threshold_uncertainty_score":0.02053523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0126714967662337,"score_gpt":0.3470690022118119,"score_spread":0.3343975054455782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}