{"id":"W2118708400","doi":"10.1016/j.semcdb.2015.11.002","title":"Protein breakdown in cancer cachexia","year":2015,"lang":"en","type":"review","venue":"Seminars in Cell and Developmental Biology","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"European Research Council; Ministero dell’Istruzione, dell’Università e della Ricerca; Fondation Leducq","keywords":"Autophagy; Lysosome; Proteasome; Protein turnover; Proteolysis; Cell biology; Protein degradation; Ubiquitin; Skeletal muscle; Cachexia; Biology; Protein catabolism; Catabolism; Sarcopenia; Biochemistry; Cancer; Metabolism; Protein biosynthesis; Endocrinology; Amino acid; Apoptosis; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004956718,0.000915186,0.001294147,0.001621273,0.0002643039,0.001001446,0.0007780356,0.001221055,0.002364416],"category_scores_gemma":[0.0004352054,0.0002480936,0.000313326,0.001814254,0.0007809068,0.0008824071,0.0009750814,0.001898439,0.001505579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007147514,"about_ca_system_score_gemma":0.0009005849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00076446,"about_ca_topic_score_gemma":0.001543523,"domain_scores_codex":[0.9998838,0.00001989093,0.00001584063,0.00002129431,0.00003900335,0.00002022877],"domain_scores_gemma":[0.9998662,0.00004978802,0.00002616902,0.000005494299,0.00003155479,0.00002066093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001796412,0.0000673914,0.0002021069,0.0126772,0.00009807075,0.0004261183,0.00004570929,0.0004037133,0.002868426,0.005010622,0.04183773,0.9361835],"study_design_scores_gemma":[0.00004384323,0.00008387692,0.001100889,0.002517383,0.0001352229,0.001929339,0.00006161889,0.0001156521,0.00094505,0.003801632,0.9892454,0.00002012263],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000857244,0.9989794,0.00009715922,0.0001809014,0.0002189066,0.00000162956,0.000009440469,0.000004271395,0.0004225028],"genre_scores_gemma":[0.001050474,0.9976235,0.0001434754,0.0001980638,0.0003181841,0.00000512258,0.00002275915,0.000001335012,0.0006370854],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002364416,"threshold_uncertainty_score":0.007909775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0244429398576718,"score_gpt":0.3138779946638098,"score_spread":0.289435054806138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}