{"id":"W2118708400","doi":"10.1016/j.semcdb.2015.11.002","title":"Protein breakdown in cancer cachexia","year":2015,"lang":"en","type":"review","venue":"Seminars in Cell and Developmental Biology","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"European Research Council; Ministero dell’Istruzione, dell’Università e della Ricerca; Fondation Leducq","keywords":"Autophagy; Lysosome; Proteasome; Protein turnover; Proteolysis; Cell biology; Protein degradation; Ubiquitin; Skeletal muscle; Cachexia; Biology; Protein catabolism; Catabolism; Sarcopenia; Biochemistry; Cancer; Metabolism; Protein biosynthesis; Endocrinology; Amino acid; Apoptosis; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000258081,0.0003737676,0.0007900872,0.0001488181,0.00003250247,0.000005892618,0.0002194303,0.0007951336,0.0000407743],"category_scores_gemma":[0.00002925839,0.0003177269,0.00007703689,0.0001649191,0.0001894178,0.0000027231,0.0003051609,0.000286906,0.00001942231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008724014,"about_ca_system_score_gemma":0.0006513844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001896884,"about_ca_topic_score_gemma":0.0004672197,"domain_scores_codex":[0.9983086,0.0001801409,0.0004247453,0.0006546166,0.00004367935,0.0003882268],"domain_scores_gemma":[0.9996029,0.00002109713,0.0001227815,0.0001524233,0.00001722778,0.00008356477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009714644,0.0001625188,0.001703195,0.002225256,0.00004691475,0.00001842199,0.0001488444,6.88277e-7,0.003660623,0.00002549403,0.001751055,0.9901599],"study_design_scores_gemma":[0.0005131097,0.0001626867,0.00005402059,0.001259874,0.00001868636,0.00002378457,0.0001218109,4.744457e-7,0.0004498603,0.0001716983,0.9967454,0.0004785997],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02516585,0.9707162,0.000001078029,0.00001065834,0.0001253402,0.0005391227,0.00004807038,0.000005743191,0.003387936],"genre_scores_gemma":[0.002544888,0.9949474,0.0002750448,0.00008186034,0.00005511771,0.0004080526,0.0007290895,0.00002644288,0.0009320793],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9949943,"threshold_uncertainty_score":0.9999275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0244429398576718,"score_gpt":0.3138779946638098,"score_spread":0.289435054806138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}