{"id":"W2118732961","doi":"10.1007/s00401-014-1291-1","title":"CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity","year":2014,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":159,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Toronto; SickKids Foundation; University of Calgary; Children's Hospital of Eastern Ontario; Hospital for Sick Children","funders":"National Cancer Institute; Canadian Institutes of Health Research; Brain Tumour Charity; Cancer Research UK","keywords":"LIN28; Biology; Pathology; Immunohistochemistry; Cerebrum; microRNA; Neuropil; Central nervous system; Medicine; Neuroscience; Gene; Immunology; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001627761,0.0002309148,0.0002194804,0.0004944677,0.0001789959,0.0003181314,0.0001785326,0.0001977553,0.0007489556],"category_scores_gemma":[0.0002967078,0.0001047605,0.0001128214,0.0003105454,0.0003332499,0.0002425726,0.0003863056,0.0002395014,0.0002128459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002620319,"about_ca_system_score_gemma":0.0003249674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007861044,"about_ca_topic_score_gemma":0.001722187,"domain_scores_codex":[0.9998956,0.00001021761,0.00001089329,0.00002629798,0.00003164151,0.00002543085],"domain_scores_gemma":[0.9998623,0.00002488718,0.00005248957,0.00001600861,0.00001580201,0.00002848172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004777951,0.00004381244,0.7356789,0.0001262426,0.00004927652,0.01744817,0.0003962784,0.0005130449,0.1966686,0.0008997206,0.000300381,0.04739778],"study_design_scores_gemma":[0.00002030473,0.0003442855,0.8148513,0.00002934374,0.00008111033,0.129462,0.0008086734,0.001580207,0.04707034,0.0008034917,0.004934135,0.00001472768],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959251,0.0006743255,0.001288612,0.00002283924,0.000002785174,0.00003515215,0.0001599499,0.0000294025,0.001861912],"genre_scores_gemma":[0.9971504,0.0004017136,0.001863784,0.00001424895,0.000004329626,0.0000206274,0.0003325974,0.00000796827,0.0002044599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007861044,"threshold_uncertainty_score":0.002505541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01509625434371525,"score_gpt":0.2385908125413009,"score_spread":0.2234945581975856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}