{"id":"W2118777015","doi":"10.1023/a:1013956215394","title":"Statin Drugs and Dietary Isoprenoids Downregulate Protein Prenylation in Signal Transduction and Are Antithrombotic and Prothrombolytic Agents","year":2002,"lang":"en","type":"review","venue":"Biochemistry (Moscow)","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Thrombin; Tissue factor; Tissue plasminogen activator; Chemistry; Plasmin; Plasminogen activator; Downregulation and upregulation; Mevalonic acid; Activator (genetics); T-plasminogen activator; Thrombomodulin; Biochemistry; Cell biology; Receptor; Biology; Coagulation; Platelet; Enzyme; Immunology; Endocrinology; Internal medicine; Medicine; Biosynthesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002011431,0.0005865165,0.0008377873,0.00008167414,0.0001064067,0.00007865587,0.0001319106,0.0006949287,0.00004195172],"category_scores_gemma":[0.00003080847,0.0005622806,0.0001098832,0.0001397063,0.0001886127,0.00001887344,0.0001340665,0.0003053962,0.000002471068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004264624,"about_ca_system_score_gemma":0.00009214239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001630579,"about_ca_topic_score_gemma":0.00000320256,"domain_scores_codex":[0.997734,0.0001257846,0.0005546341,0.001021514,0.0001996234,0.0003644776],"domain_scores_gemma":[0.9990944,0.000009651371,0.000330378,0.0003578616,0.00003990255,0.0001678012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008422546,0.0003259451,0.00006630582,0.03834792,0.0003016148,0.00002918891,0.0002091469,0.000001874241,0.6348169,0.00000766211,0.000342987,0.3254662],"study_design_scores_gemma":[0.003791098,0.00154145,0.0003430881,0.03366979,0.00134007,0.000392876,0.0002616377,0.0004317581,0.8733055,0.0004127852,0.08065691,0.003853066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1497903,0.8481035,0.00004160874,0.00002301823,0.0000483636,0.001773332,0.000129296,0.00002226689,0.00006835345],"genre_scores_gemma":[0.08781599,0.9096867,0.0005367342,0.00001945608,0.0002884377,0.0003799768,0.0005642593,0.00008511733,0.0006233074],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.3216132,"threshold_uncertainty_score":0.9996828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02364494110867314,"score_gpt":0.2702969504368502,"score_spread":0.2466520093281771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}