{"id":"W2118777015","doi":"10.1023/a:1013956215394","title":"Statin Drugs and Dietary Isoprenoids Downregulate Protein Prenylation in Signal Transduction and Are Antithrombotic and Prothrombolytic Agents","year":2002,"lang":"en","type":"review","venue":"Biochemistry (Moscow)","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Thrombin; Tissue factor; Tissue plasminogen activator; Chemistry; Plasmin; Plasminogen activator; Downregulation and upregulation; Mevalonic acid; Activator (genetics); T-plasminogen activator; Thrombomodulin; Biochemistry; Cell biology; Receptor; Biology; Coagulation; Platelet; Enzyme; Immunology; Endocrinology; Internal medicine; Medicine; Biosynthesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003829445,0.0008048238,0.001176741,0.001004581,0.0002191337,0.0006444268,0.0005490294,0.0006709676,0.002398412],"category_scores_gemma":[0.0002552278,0.0002171076,0.0002561314,0.001225261,0.0003717855,0.0007586107,0.0003229758,0.001010035,0.002229538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004410448,"about_ca_system_score_gemma":0.0006096399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005701212,"about_ca_topic_score_gemma":0.001407263,"domain_scores_codex":[0.9999095,0.00001118052,0.00001629101,0.00001614522,0.00003558839,0.00001113],"domain_scores_gemma":[0.9998587,0.00005615827,0.00002099851,0.000006941763,0.00004568981,0.00001157173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002885911,0.00008618833,0.0002017998,0.00730567,0.00006859073,0.0003837472,0.00003719166,0.0002630212,0.01574248,0.002961888,0.01226209,0.9603989],"study_design_scores_gemma":[0.00007772454,0.0002250609,0.001811167,0.0008447282,0.0001861346,0.002079548,0.00005947266,0.0001286035,0.01001766,0.001831353,0.9827161,0.00002243185],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007063313,0.9960846,0.0006946734,0.0002796384,0.0003439608,0.000008762488,0.00003550504,0.00001726647,0.001829357],"genre_scores_gemma":[0.002555538,0.9938242,0.0008446525,0.0001925377,0.0001945743,0.00001560456,0.00006700026,0.00000315257,0.002302636],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002398412,"threshold_uncertainty_score":0.008023441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02364494110867314,"score_gpt":0.2702969504368502,"score_spread":0.2466520093281771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}