{"id":"W2118784070","doi":"10.1186/1750-9378-3-11","title":"Antibodies to the CD4-binding site of HIV-1 gp120 suppress gp120-specific CD4 T cell response while enhancing antibody response","year":2008,"lang":"en","type":"article","venue":"Infectious Agents and Cancer","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Center for AIDS Research, University of Washington; National Institutes of Health; York University; National Institute of Allergy and Infectious Diseases; U.S. Department of Veterans Affairs","keywords":"Biology; Epitope; In vivo; Antibody; Monoclonal antibody; Immune system; Virology; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002622216,0.0008767374,0.000365811,0.0003875337,0.0001722321,0.0003533685,0.0003743891,0.0005216392,0.002087289],"category_scores_gemma":[0.0002100392,0.000201269,0.0002976285,0.000117679,0.0003780084,0.0002546772,0.0002176874,0.001568414,0.0004807949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003293869,"about_ca_system_score_gemma":0.0002269375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002235557,"about_ca_topic_score_gemma":0.0003102113,"domain_scores_codex":[0.9996598,0.00005257778,0.0000264746,0.00005373282,0.00008125795,0.0001261775],"domain_scores_gemma":[0.9996679,0.00009015376,0.00006437411,0.00003841512,0.00003501208,0.0001041609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002415717,0.000241825,0.0002211455,0.00004667978,0.000007740607,0.0000254387,0.000009767544,0.00004489057,0.9980289,0.00008998348,0.00004160188,0.001000359],"study_design_scores_gemma":[0.0001003426,0.002268626,0.003260102,0.00002092705,0.0000340638,0.0002499481,0.00001750219,0.0009092822,0.9914951,0.00007112203,0.001568566,0.000004404305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961966,0.0008619204,0.001008518,0.00008019304,0.00003598311,0.00004825347,0.00009368248,0.00005750661,0.001617357],"genre_scores_gemma":[0.9943213,0.0006233228,0.001811324,0.0001329969,0.00008575345,0.000086163,0.0003369431,0.00002340861,0.002578808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002087289,"threshold_uncertainty_score":0.006982684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02030081689837092,"score_gpt":0.2879264493246382,"score_spread":0.2676256324262673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}