{"id":"W2118837528","doi":"10.1158/1078-0432.ccr-10-0395","title":"HDAC5 and HDAC9 in Medulloblastoma: Novel Markers for Risk Stratification and Role in Tumor Cell Growth","year":2010,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":193,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Bundesministerium für Bildung und Forschung","keywords":"Medulloblastoma; Histone deacetylase 5; Gene knockdown; Cancer research; Biology; Histone deacetylase; Immunology; Oncology; Medicine; Cell culture; Histone; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004135638,0.0001156379,0.0001944461,0.0001619549,0.00009814511,0.00004351254,0.0002161147,0.0002506304,0.00001998791],"category_scores_gemma":[0.002472932,0.0001133146,0.00004569138,0.0002308671,0.0006492792,0.000008909144,0.0001813596,0.0009992979,0.000003537987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000385447,"about_ca_system_score_gemma":0.0004166359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008724088,"about_ca_topic_score_gemma":0.009716047,"domain_scores_codex":[0.9979007,0.0002752086,0.0004222875,0.0006589745,0.0002825144,0.0004603331],"domain_scores_gemma":[0.998688,0.0004852109,0.00006385843,0.0003070674,0.0002420538,0.0002138159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001336287,0.0003544753,0.09307039,0.0001027328,0.00001140301,0.000004993025,0.00007853724,0.00000358772,0.8954968,0.0001201448,0.001730305,0.007690285],"study_design_scores_gemma":[0.01134963,0.002534806,0.3483797,0.0001019816,0.00001642001,0.0000152114,0.0006890131,0.003581324,0.6001616,0.001379253,0.031079,0.0007120473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975176,0.0006221147,0.00003129393,0.0004089087,0.00009332256,0.0006977536,0.00007373466,0.000004034544,0.0005512012],"genre_scores_gemma":[0.9974826,0.0008471084,0.0006254558,0.0000341442,0.0002674651,0.0003571004,0.00002555401,0.00002540787,0.0003351669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2953353,"threshold_uncertainty_score":0.5421782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04207828477692169,"score_gpt":0.4311376314385805,"score_spread":0.3890593466616588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}