{"id":"W2118838697","doi":"10.4049/jimmunol.1401781","title":"Complement Opsonization of HIV-1 Results in Decreased Antiviral and Inflammatory Responses in Immature Dendritic Cells via CR3","year":2014,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"Svenska Läkaresällskapet; Svenska Sällskapet för Medicinsk Forskning; Frederick National Laboratory for Cancer Research; Leidos; National Cancer Institute; National Institutes of Health; Vetenskapsrådet; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Antibody opsonization; Opsonin; Complement system; Immunology; Biology; SAMHD1; Complement receptor; Immune system; Virology; iC3b; Antibody; Reverse transcriptase; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009262044,0.0002300101,0.0002848103,0.0001289287,0.0001124374,0.0002878889,0.0001702795,0.0002549675,0.001379161],"category_scores_gemma":[0.0001660789,0.0001016683,0.0002646983,0.00009651458,0.0001467335,0.0001680184,0.0001243681,0.0006822496,0.0002454935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000228779,"about_ca_system_score_gemma":0.0002292766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001009371,"about_ca_topic_score_gemma":0.0009264073,"domain_scores_codex":[0.9998154,0.00002315448,0.00001676113,0.00003369085,0.00003127404,0.00007973898],"domain_scores_gemma":[0.9999335,0.000009850688,0.00001308748,0.000008684915,0.00001247345,0.00002231625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003328134,0.00004335113,0.0002608707,0.00004012155,0.000003721401,0.00004926429,0.0000148231,0.00001459627,0.9982594,0.0000333565,0.00004201704,0.0009056391],"study_design_scores_gemma":[0.00006269399,0.001174753,0.01449296,0.00001141523,0.00004426176,0.000482349,0.00007065162,0.0004477612,0.9811478,0.00005810535,0.00200063,0.00000656387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979372,0.0008229492,0.0003827885,0.00006091273,0.00001934822,0.00001731688,0.0002149662,0.00002260582,0.0005218397],"genre_scores_gemma":[0.9973437,0.0003506427,0.0005481463,0.00008402304,0.00000947662,0.00003043983,0.0003865583,0.000008494049,0.001238535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001379161,"threshold_uncertainty_score":0.004613757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009450919365629716,"score_gpt":0.2503385198511983,"score_spread":0.2408876004855685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}