{"id":"W2118852930","doi":"10.1172/jci28277","title":"A public T cell clonotype within a heterogeneous autoreactive repertoire is dominant in driving EAE","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Multiple Sclerosis Society; University of California Davis School of Medicine; National Multiple Sclerosis Society","keywords":"Experimental autoimmune encephalomyelitis; Immunology; Multiple sclerosis; Biology; Repertoire; Spleen; Myelin basic protein; Lymph; T cell; Immunization; Myelin; Neuroscience; Medicine; Immune system; Central nervous system; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002077712,0.0002635198,0.0002308648,0.0003030121,0.0001712564,0.0003183217,0.0001155092,0.0002330527,0.0009883407],"category_scores_gemma":[0.0002042372,0.0001721142,0.0001212232,0.0001116513,0.0002109476,0.0001904326,0.0002629371,0.00045807,0.0003194204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000188968,"about_ca_system_score_gemma":0.0001825387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002542759,"about_ca_topic_score_gemma":0.0007105857,"domain_scores_codex":[0.9997368,0.00003653756,0.00001293757,0.00003539434,0.00006931125,0.0001088903],"domain_scores_gemma":[0.9997662,0.00003580062,0.00005969864,0.00003105353,0.00002473254,0.00008245069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000149086,0.00005025502,0.003380003,0.00001765408,0.000003334281,0.00009362355,0.00001680189,0.0000364154,0.9949302,0.00006630052,0.00001826481,0.001238049],"study_design_scores_gemma":[0.0001166024,0.002651806,0.1599009,0.0000619565,0.0001284488,0.006452224,0.000238016,0.002910536,0.8235505,0.0006122001,0.003357294,0.00001950694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986626,0.0002131195,0.0004186418,0.00001148261,0.000002302609,0.000005946223,0.00004243287,0.00002033374,0.0006231687],"genre_scores_gemma":[0.9990031,0.0001341397,0.0003138609,0.00001452434,0.000007588754,0.000006268169,0.0001095357,0.000007926429,0.0004029483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009883407,"threshold_uncertainty_score":0.003306329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05858409325426539,"score_gpt":0.3137709818482216,"score_spread":0.2551868885939562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}