{"id":"W2118884969","doi":"10.1093/toxsci/kfs138","title":"Oxoguanine Glycosylase 1 (OGG1) Protects Cells from DNA Double-Strand Break Damage Following Methylmercury (MeHg) Exposure","year":2012,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Mercury impact and mitigation studies","field":"Environmental Science","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"University of Toronto; Canadian Institutes of Health Research; Cancer Research Society","keywords":"DNA damage; Oxidative stress; DNA glycosylase; DNA repair; Chemistry; Clonogenic assay; Comet assay; Reactive oxygen species; Apoptosis; DNA fragmentation; Programmed cell death; DNA; Biochemistry; Molecular biology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001252416,0.0005371036,0.0004249581,0.0002600111,0.0001402788,0.0002124293,0.0002022636,0.000436109,0.0005923352],"category_scores_gemma":[0.00009962518,0.0001522278,0.0002593946,0.0001699615,0.0001674954,0.0002093828,0.0001973731,0.0004478231,0.000189665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001730633,"about_ca_system_score_gemma":0.0002052763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009170569,"about_ca_topic_score_gemma":0.001157628,"domain_scores_codex":[0.9999044,0.0000130036,0.00001273704,0.00002471563,0.00002340507,0.0000217783],"domain_scores_gemma":[0.9999171,0.000007987287,0.00002896491,0.000009190497,0.00001540934,0.00002137507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008941462,0.00001706379,0.0004730836,0.00004100072,0.000006920528,0.0000359411,0.00001559503,0.00001914438,0.9983851,0.00001380896,0.00001385891,0.0008892433],"study_design_scores_gemma":[0.000007250523,0.0004847133,0.01506143,0.000008517586,0.0000224915,0.0001645941,0.00004249121,0.0001698697,0.9830896,0.00002198558,0.0009232021,0.00000381027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926568,0.004432305,0.001883521,0.00008089273,0.00004745182,0.0000266481,0.0002603169,0.00008536783,0.0005266892],"genre_scores_gemma":[0.9923867,0.003304543,0.001873375,0.00007062986,0.0000127713,0.00003911167,0.0005543059,0.00001130654,0.001747308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009170569,"threshold_uncertainty_score":0.001981497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0489524086542384,"score_gpt":0.2959855885172839,"score_spread":0.2470331798630455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}