{"id":"W2118897675","doi":"10.1093/infdis/jit395","title":"Targeting of the Purine Biosynthesis Host Cell Pathway Enhances the Activity of Tenofovir Against Sensitive and Drug-Resistant HIV-1","year":2013,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"National Institutes of Health; McGill University","keywords":"Resveratrol; Biology; Ribonucleotide reductase; Pharmacology; Nucleoside; Virology; Drug resistance; Biochemistry; Microbiology; Protein subunit","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001599276,0.0002794282,0.0002260377,0.0001808288,0.0001032439,0.0003382007,0.0001790973,0.0001893697,0.001700345],"category_scores_gemma":[0.0001050358,0.0000768439,0.0001869326,0.00008263913,0.000143201,0.0002061149,0.0001239572,0.0004423867,0.0002785823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001927627,"about_ca_system_score_gemma":0.0001651816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004049093,"about_ca_topic_score_gemma":0.0009667934,"domain_scores_codex":[0.9998921,0.00002374408,0.00001002837,0.00001941245,0.00002653825,0.00002815917],"domain_scores_gemma":[0.9999256,0.00001639214,0.0000174567,0.000008920391,0.00001057856,0.00002107724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001489162,0.00008550599,0.0001205448,0.000055029,0.000006563983,0.00001826028,0.00001089613,0.00009886816,0.9957635,0.00007306388,0.00005259012,0.003566183],"study_design_scores_gemma":[0.00003263503,0.001964386,0.003285817,0.00001474195,0.00004708951,0.0001811684,0.00001977462,0.0007034148,0.9894339,0.00004555197,0.00426579,0.000005669604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906764,0.003449671,0.001799904,0.000111823,0.00005027517,0.00004074794,0.0002207465,0.00007911408,0.003571221],"genre_scores_gemma":[0.994634,0.001479964,0.001795725,0.00005309593,0.00001510127,0.0000152023,0.000283833,0.00001103477,0.001711987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001700345,"threshold_uncertainty_score":0.00568819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003287441605211694,"score_gpt":0.200868396665468,"score_spread":0.1975809550602563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}