{"id":"W2118899477","doi":"10.1038/ng.2439","title":"CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation","year":2012,"lang":"en","type":"article","venue":"Nature Genetics","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":112,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Center for Research Resources; National Institute of General Medical Sciences","keywords":"LYN; Tyrosine-protein kinase CSK; PTPN22; Biology; Src family kinase; Lupus erythematosus; Tyrosine kinase; Immunology; Systemic lupus erythematosus; Molecular biology; Signal transduction; Cell biology; Single-nucleotide polymorphism; Internal medicine; Genetics; Genotype; Antibody; Gene; Medicine; SH3 domain","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001912637,0.0002249136,0.0002806093,0.00009931634,0.0002103654,0.00001935896,0.0001128463,0.0009488864,0.00003580806],"category_scores_gemma":[0.00002836176,0.0001769995,0.00002892354,0.0001213983,0.0002607227,0.00009252886,0.00007322795,0.0005875845,0.00001798582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000327315,"about_ca_system_score_gemma":0.00003743271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000900037,"about_ca_topic_score_gemma":0.000002572041,"domain_scores_codex":[0.9989358,0.0001260515,0.0002151365,0.0002674535,0.000056303,0.0003993149],"domain_scores_gemma":[0.99933,0.0001406247,0.000205349,0.0002055273,0.00008107988,0.00003736833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006299235,0.00006711413,0.09200102,0.00003430671,0.0001490018,0.000001611221,0.001043843,0.00000186956,0.9056736,0.00005747219,0.0004669149,0.000440279],"study_design_scores_gemma":[0.002103302,0.0002114561,0.01557993,0.0001453949,0.0001572958,0.0008950841,0.0005975466,0.000003849693,0.9769223,0.00008798254,0.002951474,0.000344353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9163504,0.08263922,0.00001507697,0.00007128161,0.0005253868,0.0001728462,0.00001188869,0.00005232636,0.0001616128],"genre_scores_gemma":[0.997713,0.0004211132,0.00009889862,0.0003124145,0.00005356605,0.000007924473,0.00003536657,0.0000235738,0.001334199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08221811,"threshold_uncertainty_score":0.7318681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00704448398646388,"score_gpt":0.2050421165751051,"score_spread":0.1979976325886412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}