{"id":"W2118899477","doi":"10.1038/ng.2439","title":"CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation","year":2012,"lang":"en","type":"article","venue":"Nature Genetics","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":112,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Center for Research Resources; National Institute of General Medical Sciences","keywords":"LYN; Tyrosine-protein kinase CSK; PTPN22; Biology; Src family kinase; Lupus erythematosus; Tyrosine kinase; Immunology; Systemic lupus erythematosus; Molecular biology; Signal transduction; Cell biology; Single-nucleotide polymorphism; Internal medicine; Genetics; Genotype; Antibody; Gene; Medicine; SH3 domain","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004020715,0.001028711,0.0004692683,0.001490112,0.00044145,0.00044103,0.0005332629,0.000772614,0.006669708],"category_scores_gemma":[0.0009849379,0.0002747851,0.0006062277,0.001046492,0.0004858972,0.0002137151,0.0002869717,0.0007156279,0.0006133774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002640764,"about_ca_system_score_gemma":0.0002316603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001159638,"about_ca_topic_score_gemma":0.000868043,"domain_scores_codex":[0.9993568,0.0002017401,0.00009332313,0.0001744573,0.00009121227,0.00008245955],"domain_scores_gemma":[0.9983397,0.0005291704,0.0006029307,0.0001127533,0.00008124093,0.0003342572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01456111,0.000770548,0.2081799,0.0001594165,0.0007930533,0.006038862,0.0003353647,0.0005750853,0.7550151,0.001261819,0.0007497633,0.01155993],"study_design_scores_gemma":[0.0007203159,0.001219767,0.9071969,0.00009237179,0.0009457491,0.01998671,0.000256872,0.00400299,0.06137136,0.001217027,0.002875661,0.0001143722],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982652,0.0001561394,0.0006271457,0.000102458,0.00002687583,0.000007126305,0.0001778879,0.00004068969,0.0005964498],"genre_scores_gemma":[0.9986826,0.00005873347,0.0004588774,0.00004783972,0.00003930781,0.000006245254,0.0001347277,0.00003683932,0.0005349549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006669708,"threshold_uncertainty_score":0.02231234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00704448398646388,"score_gpt":0.2050421165751051,"score_spread":0.1979976325886412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}