{"id":"W2118910385","doi":"10.1007/s11307-010-0380-3","title":"Isoflurane Anaesthesia Differentially Affects the Amphetamine Sensitivity of Agonist and Antagonist D2/D3 Positron Emission Tomography Radiotracers: Implications for In Vivo Imaging of Dopamine Release","year":2010,"lang":"en","type":"article","venue":"Molecular Imaging and Biology","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research","keywords":"Raclopride; Binding potential; Isoflurane; Chemistry; Dopamine; Amphetamine; Agonist; Pharmacology; Antagonist; Dopamine receptor D2; Anesthesia; Internal medicine; Medicine; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002671407,0.0001919064,0.0002818722,0.0001626116,0.00013549,0.00003793502,0.0001534522,0.00005039581,0.000002192911],"category_scores_gemma":[0.000137714,0.0001466164,0.00008480522,0.0002158064,0.0007657782,0.00007574223,0.00005478832,0.0002014126,8.149127e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007214007,"about_ca_system_score_gemma":0.00002845462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001633781,"about_ca_topic_score_gemma":0.00003082405,"domain_scores_codex":[0.9986735,0.0002661452,0.0002578055,0.0004627896,0.00006481706,0.0002749297],"domain_scores_gemma":[0.9991646,0.0002356862,0.0001631224,0.0003202346,0.00004186957,0.00007449285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004699994,0.00007657431,0.184179,0.00003439815,0.000002377749,0.000008694692,0.00004202847,7.034824e-7,0.7986842,0.0001958223,0.000005494391,0.01672366],"study_design_scores_gemma":[0.0005783237,0.00008006803,0.1102689,0.00002735047,0.00003708071,0.0001805758,0.00001168737,0.0004614675,0.8879402,0.0001007068,0.000176928,0.0001366973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932345,0.0001971673,0.002796867,0.003097058,0.00007685235,0.0004881771,0.00007288159,0.00002576988,0.00001068439],"genre_scores_gemma":[0.9991393,0.00006334306,0.0004093295,0.0003176065,0.00001331172,0.00002493195,0.000007752164,0.00002009613,0.000004299114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08925597,"threshold_uncertainty_score":0.5978844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0109717911402619,"score_gpt":0.2727603719360809,"score_spread":0.261788580795819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}