{"id":"W2118910385","doi":"10.1007/s11307-010-0380-3","title":"Isoflurane Anaesthesia Differentially Affects the Amphetamine Sensitivity of Agonist and Antagonist D2/D3 Positron Emission Tomography Radiotracers: Implications for In Vivo Imaging of Dopamine Release","year":2010,"lang":"en","type":"article","venue":"Molecular Imaging and Biology","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research","keywords":"Raclopride; Binding potential; Isoflurane; Chemistry; Dopamine; Amphetamine; Agonist; Pharmacology; Antagonist; Dopamine receptor D2; Anesthesia; Internal medicine; Medicine; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000290853,0.0003877017,0.0003979125,0.0002523549,0.0002544551,0.0005585667,0.0003877632,0.000423599,0.00138762],"category_scores_gemma":[0.0006197134,0.0003514415,0.0002487682,0.0001787593,0.0006382804,0.0005299198,0.0001877664,0.0005836182,0.0002495635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005039945,"about_ca_system_score_gemma":0.0004578145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002052266,"about_ca_topic_score_gemma":0.003597,"domain_scores_codex":[0.9997597,0.00005184874,0.00001614554,0.00002953227,0.00005710785,0.00008574776],"domain_scores_gemma":[0.9996668,0.0001122043,0.00009277555,0.00004176867,0.00002801073,0.00005837636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003144599,0.0000443774,0.0006163008,0.00001807384,0.00002192843,0.00004939852,0.00003107395,0.00005209494,0.9935192,0.0002006895,0.00005171483,0.002250399],"study_design_scores_gemma":[0.0001241758,0.001319345,0.02851033,0.00000624751,0.0001092297,0.0004436698,0.00007851757,0.001480367,0.966518,0.0002243181,0.001164908,0.0000207884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960057,0.0009903935,0.001745852,0.0001614088,0.00003416378,0.00002124604,0.0001533564,0.00004300934,0.0008448399],"genre_scores_gemma":[0.9961334,0.001062848,0.001272786,0.000115022,0.00001790353,0.00003415399,0.0002881222,0.00006439056,0.001011226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002052266,"threshold_uncertainty_score":0.004642069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0109717911402619,"score_gpt":0.2727603719360809,"score_spread":0.261788580795819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}