{"id":"W2118922417","doi":"10.1158/1078-0432.ccr-11-2094","title":"Prognostic and Predictive Significance of Plasma HGF and IL-8 in a Phase III Trial of Chemoradiation with or without Tirapazamine in Locoregionally Advanced Head and Neck Cancer","year":2012,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Hepatocyte growth factor; Tirapazamine; Medicine; Head and neck cancer; Cisplatin; Oncology; Tumor hypoxia; Internal medicine; Radiation therapy; Cancer research; Cancer; Chemotherapy; Biology; In vitro; Cytotoxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001003031,0.0001296771,0.0004595745,0.0001008975,0.00002676435,0.00000749687,0.00008605183,0.0001490467,0.000008159091],"category_scores_gemma":[0.0004759998,0.0001011028,0.00002594435,0.0002579529,0.0006913071,0.00002034752,0.00008224697,0.0002581199,6.691995e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002647201,"about_ca_system_score_gemma":0.000538329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005053341,"about_ca_topic_score_gemma":0.00312936,"domain_scores_codex":[0.9983657,0.0001817978,0.0004715179,0.0003943057,0.0002624761,0.0003242252],"domain_scores_gemma":[0.9990889,0.0002220302,0.0001621983,0.000170357,0.0001880474,0.0001684037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3317873,0.001432709,0.4707974,0.0004136256,0.0001164725,0.000002568462,0.0007929943,0.00006294338,0.06689297,0.00003002005,0.0001775116,0.1274934],"study_design_scores_gemma":[0.3266281,0.01648384,0.6040484,0.0009585924,0.0001255465,0.00001277802,0.0006813859,0.001664012,0.0345182,0.00006776807,0.0142374,0.0005740094],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991104,0.007176577,0.00002286955,0.0001289453,0.000134175,0.00129113,0.00010486,0.000002116997,0.00003532776],"genre_scores_gemma":[0.9837634,0.01479032,0.0001845332,0.00002914405,0.0005546252,0.0005258564,0.00001775034,0.00001691237,0.0001174447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.133251,"threshold_uncertainty_score":0.4122851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09141139621870341,"score_gpt":0.4533343857705327,"score_spread":0.3619229895518293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}