{"id":"W2118922417","doi":"10.1158/1078-0432.ccr-11-2094","title":"Prognostic and Predictive Significance of Plasma HGF and IL-8 in a Phase III Trial of Chemoradiation with or without Tirapazamine in Locoregionally Advanced Head and Neck Cancer","year":2012,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Hepatocyte growth factor; Tirapazamine; Medicine; Head and neck cancer; Cisplatin; Oncology; Tumor hypoxia; Internal medicine; Radiation therapy; Cancer research; Cancer; Chemotherapy; Biology; In vitro; Cytotoxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001801647,0.0007216244,0.001417737,0.0002214318,0.0002588108,0.0006505583,0.0006140987,0.0007711249,0.000970711],"category_scores_gemma":[0.001475934,0.0003608271,0.001026261,0.0002593901,0.0006827504,0.0003833267,0.0002435466,0.001419834,0.0002397801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007985142,"about_ca_system_score_gemma":0.001029628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006235341,"about_ca_topic_score_gemma":0.001850442,"domain_scores_codex":[0.9992744,0.0004123593,0.00004308848,0.000104306,0.00007392639,0.00009182579],"domain_scores_gemma":[0.999087,0.000297159,0.0002178528,0.00008824397,0.00004747257,0.0002622861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8988367,0.009802446,0.03104268,0.0002327146,0.001545084,0.00009638861,0.0001717305,0.001424728,0.02219291,0.00005976315,0.0005268713,0.03406787],"study_design_scores_gemma":[0.4153411,0.4441848,0.1272556,0.00003876029,0.002221661,0.0002808869,0.00009694616,0.003346881,0.005749145,0.0001857759,0.001256652,0.00004174672],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990529,0.0004379037,0.00006704515,0.00006699192,0.00001787116,0.0001563159,0.00007274837,0.000006094075,0.0001221256],"genre_scores_gemma":[0.9987129,0.000199917,0.0001905514,0.00009582988,0.00003527651,0.0002927686,0.0002743924,0.000003027551,0.0001953316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001801647,"threshold_uncertainty_score":0.0095281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09141139621870341,"score_gpt":0.4533343857705327,"score_spread":0.3619229895518293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}