{"id":"W2118942884","doi":"10.18433/j36w2j","title":"In Situ Intestinal Perfusion of Irinotecan: Application to P-gp Mediated Drug Interaction and Introduction of an Improved HPLC Assay","year":2011,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"China Scholarship Council; National Natural Science Foundation of China","keywords":"Irinotecan; Verapamil; Intestinal permeability; Perfusion; Pharmacology; Metabolite; Chemistry; Pharmacokinetics; High-performance liquid chromatography; Prodrug; In vivo; Active metabolite; Permeability (electromagnetism); Camptothecin; Toxicity; Chromatography; Medicine; Internal medicine; Biology; Biochemistry; Calcium; Cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001127305,0.00009242475,0.0001534494,0.0001448554,0.00003288552,0.000009415538,0.0001967924,0.0000290535,0.00004303302],"category_scores_gemma":[0.00006581993,0.00007621347,0.00004304968,0.000229974,0.0001394854,0.00004443506,0.0000667381,0.0001425526,5.027339e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002300506,"about_ca_system_score_gemma":0.00008024728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009713531,"about_ca_topic_score_gemma":0.00004044995,"domain_scores_codex":[0.9989637,0.00009793384,0.0004072902,0.0001949666,0.0001953571,0.00014073],"domain_scores_gemma":[0.9992957,0.0000216987,0.0002810032,0.0000752345,0.0001874437,0.0001389088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00069426,0.0002160354,0.0003957547,0.00001510704,0.000009568083,7.312934e-7,0.0002770876,0.0000289808,0.9242455,0.00006529344,0.00003782835,0.07401384],"study_design_scores_gemma":[0.0007410211,0.0007586222,0.0005020188,0.00001324823,0.00003020804,0.00005431516,0.0002153971,0.004445991,0.9797357,0.000107005,0.01331607,0.00008042868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956218,0.0002465582,0.002928586,0.0006322063,0.0002770195,0.0001506693,0.000002530245,0.000001992839,0.0001386297],"genre_scores_gemma":[0.9969898,0.0003625539,0.002138579,0.0002151638,0.0002734593,0.000004037462,0.000002197405,0.000005536522,0.000008631663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07393342,"threshold_uncertainty_score":0.3107895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03611591687853888,"score_gpt":0.3655345785278571,"score_spread":0.3294186616493183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}