{"id":"W2118942884","doi":"10.18433/j36w2j","title":"In Situ Intestinal Perfusion of Irinotecan: Application to P-gp Mediated Drug Interaction and Introduction of an Improved HPLC Assay","year":2011,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"China Scholarship Council; National Natural Science Foundation of China","keywords":"Irinotecan; Verapamil; Intestinal permeability; Perfusion; Pharmacology; Metabolite; Chemistry; Pharmacokinetics; High-performance liquid chromatography; Prodrug; In vivo; Active metabolite; Permeability (electromagnetism); Camptothecin; Toxicity; Chromatography; Medicine; Internal medicine; Biology; Biochemistry; Calcium; Cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004085213,0.0006427299,0.0004278283,0.0003135369,0.0001724045,0.000354073,0.0003759167,0.0005354543,0.0009702103],"category_scores_gemma":[0.0003713585,0.0002761039,0.000239114,0.0002523077,0.0003194316,0.0004596754,0.000240467,0.0009190732,0.0003796552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000355083,"about_ca_system_score_gemma":0.0003147409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006365882,"about_ca_topic_score_gemma":0.0009750234,"domain_scores_codex":[0.9994015,0.0001471956,0.00002459976,0.0001997551,0.0001786948,0.00004839402],"domain_scores_gemma":[0.9997692,0.00005985068,0.00007145414,0.00002650327,0.00005189919,0.00002114956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003573957,0.00001388792,0.00009938722,0.00004504387,0.00000480786,0.00003561592,0.00001017066,0.00003400258,0.997925,0.00003188227,0.00002313672,0.001741459],"study_design_scores_gemma":[0.000007154036,0.0002853301,0.001491694,0.000004460423,0.000022975,0.0003040224,0.0000100244,0.001367245,0.9948006,0.00002892473,0.001669944,0.000007645163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6818055,0.009853092,0.3008082,0.0007343687,0.0002736741,0.0004246515,0.0007609248,0.001232361,0.004107272],"genre_scores_gemma":[0.8178577,0.006654213,0.1660886,0.00034011,0.0001670928,0.0005469521,0.0007999347,0.0001094316,0.007435963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009702103,"threshold_uncertainty_score":0.003245711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03611591687853888,"score_gpt":0.3655345785278571,"score_spread":0.3294186616493183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}