{"id":"W2118971140","doi":"10.1126/scisignal.2004712","title":"Protein Interaction Network of the Mammalian Hippo Pathway Reveals Mechanisms of Kinase-Phosphatase Interactions","year":2013,"lang":"en","type":"article","venue":"Science Signaling","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":468,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Cell biology; Hippo signaling pathway; Phosphatase; Kinase; Biology; Protein phosphatase 1; Protein kinase A; Protein phosphatase 2; Chemistry; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008510594,0.000133679,0.0001544748,0.00004976338,0.0002398406,0.00004004481,0.000495295,0.00006511503,0.0001149776],"category_scores_gemma":[0.0002569739,0.0001001144,0.000120142,0.0004658932,0.0002927226,0.00002978551,0.0001578813,0.0001370439,0.00001362881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002611404,"about_ca_system_score_gemma":0.0002024309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001337588,"about_ca_topic_score_gemma":0.00001111097,"domain_scores_codex":[0.998572,0.0001009733,0.0003795666,0.0003325143,0.0003062833,0.000308671],"domain_scores_gemma":[0.9987662,0.00002251115,0.000336651,0.0004568533,0.0003304763,0.00008729666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000138075,0.00003484959,0.0001497774,0.00001974196,0.000007674903,3.748987e-7,0.00007284327,0.001280097,0.9954546,0.001364638,0.00005184052,0.001549721],"study_design_scores_gemma":[0.0001110327,0.0001339045,0.0001808345,0.0001821933,0.000008640509,0.000005161734,0.0002593873,0.0003406088,0.9948322,0.003471409,0.0003592349,0.0001153952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99219,0.000105482,0.006312627,0.0001143994,0.0004511148,0.0004057331,0.00001939501,0.00001025628,0.0003909601],"genre_scores_gemma":[0.9961497,0.000001713403,0.00322044,0.00008898839,0.0001130263,0.00004479773,0.00001223302,0.0000125642,0.0003565463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003959659,"threshold_uncertainty_score":0.4082546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01285113842498356,"score_gpt":0.244969096046465,"score_spread":0.2321179576214814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}