{"id":"W2118971711","doi":"10.2174/156802610791113469","title":"Therapeutic Utility and Medicinal Chemistry of Cathepsin C Inhibitors","year":2010,"lang":"en","type":"review","venue":"Current Topics in Medicinal Chemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Proteases; Cathepsin C; Cathepsin G; Chemistry; Cathepsin; Biochemistry; Serine; Serine protease; Pharmacology; Serine Proteinase Inhibitors; Protease; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003617685,0.0005797753,0.0003018677,0.000581885,0.0001963926,0.0006820087,0.0003328469,0.000526068,0.001822683],"category_scores_gemma":[0.0002791329,0.0002036649,0.000325478,0.0003732967,0.0003616018,0.0004253687,0.0003964987,0.001087602,0.0007267053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005426619,"about_ca_system_score_gemma":0.0002727853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004050267,"about_ca_topic_score_gemma":0.0005026627,"domain_scores_codex":[0.9998212,0.00004452069,0.000009052778,0.00003805479,0.00004897804,0.00003816302],"domain_scores_gemma":[0.9999183,0.00001548475,0.00002204642,0.000008065103,0.00001982643,0.00001624903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001138739,0.0007907007,0.0005177888,0.003135311,0.0001353372,0.0009395021,0.000170674,0.008990619,0.5662361,0.03246637,0.01073304,0.3747458],"study_design_scores_gemma":[0.0005334704,0.00700922,0.002536935,0.0005163897,0.0001561128,0.003517283,0.00008785022,0.005746041,0.5158852,0.007396983,0.4565062,0.0001082378],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2102938,0.6517928,0.03426382,0.004221703,0.001079563,0.0003544971,0.001486154,0.0004506419,0.09605715],"genre_scores_gemma":[0.710152,0.2661735,0.007471947,0.001505,0.0003799562,0.0001575912,0.0007735169,0.00003321521,0.01335328],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001822683,"threshold_uncertainty_score":0.006097496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05911974874436363,"score_gpt":0.3784413533144509,"score_spread":0.3193216045700873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}