{"id":"W2118978929","doi":"10.18433/j3s88w","title":"Bioreduction of Idarubicin and Formation of ROS Responsible for DNA Cleavage by NADPH-Cytochrome P450 Reductase and its Potential Role in the Antitumor Effect","year":2009,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; Orta Doğu Teknik Üniversitesi","keywords":"Idarubicin; Reductase; DNA damage; Biochemistry; Chemistry; Cytochrome P450 reductase; Cytochrome P450; Reactive oxygen species; Enzyme; Catalase; DNA; Pharmacology; Biology; Cytochrome c; Coenzyme Q – cytochrome c reductase; Apoptosis; Cytarabine; Cancer research","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000227067,0.0002843034,0.0002139296,0.0001802288,0.00009686079,0.0002068861,0.0001913605,0.0002644463,0.0007297467],"category_scores_gemma":[0.0002366043,0.0001007628,0.000261031,0.0001102516,0.000171047,0.0001956967,0.000113501,0.0003536381,0.0002451847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002570214,"about_ca_system_score_gemma":0.0002242739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004152696,"about_ca_topic_score_gemma":0.000307093,"domain_scores_codex":[0.9998547,0.00004263398,0.00001158741,0.00002930255,0.00003960802,0.00002219179],"domain_scores_gemma":[0.999897,0.00002132174,0.00002976503,0.00001321538,0.00002595988,0.00001262577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001124442,0.0000366192,0.0007731213,0.00006568051,0.000008037568,0.0001040043,0.00001864568,0.0001289003,0.9962537,0.0001713106,0.00002120038,0.002306244],"study_design_scores_gemma":[0.000006723747,0.0002604857,0.00198959,0.000005604811,0.0000144672,0.0002090229,0.00001932756,0.001015012,0.9955349,0.00008320288,0.0008587945,0.000002794846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789216,0.007038068,0.01210919,0.0002035707,0.00005228931,0.00004951781,0.0001350583,0.00006522975,0.001425474],"genre_scores_gemma":[0.9939639,0.001242435,0.003670035,0.00003196147,0.00001142236,0.00001564863,0.0001591476,0.000004354853,0.0009010781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007297467,"threshold_uncertainty_score":0.002441227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02920790178701956,"score_gpt":0.3765117536613514,"score_spread":0.3473038518743318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}