{"id":"W2118978929","doi":"10.18433/j3s88w","title":"Bioreduction of Idarubicin and Formation of ROS Responsible for DNA Cleavage by NADPH-Cytochrome P450 Reductase and its Potential Role in the Antitumor Effect","year":2009,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; Orta Doğu Teknik Üniversitesi","keywords":"Idarubicin; Reductase; DNA damage; Biochemistry; Chemistry; Cytochrome P450 reductase; Cytochrome P450; Reactive oxygen species; Enzyme; Catalase; DNA; Pharmacology; Biology; Cytochrome c; Coenzyme Q – cytochrome c reductase; Apoptosis; Cytarabine; Cancer research","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002372919,0.0001082868,0.0003023866,0.0002065714,0.00009968032,0.00002857598,0.0001117743,0.00003725667,0.000008782311],"category_scores_gemma":[0.0001602285,0.00007127917,0.00009425043,0.000370348,0.0002341808,0.0005426153,0.00001095366,0.0002013198,1.645987e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003342599,"about_ca_system_score_gemma":0.0001046923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006793145,"about_ca_topic_score_gemma":3.519023e-7,"domain_scores_codex":[0.9985623,0.0001779019,0.000484043,0.0001330958,0.0004589819,0.0001836235],"domain_scores_gemma":[0.9992757,0.0001546624,0.0002984714,0.00004957441,0.0001088465,0.0001126877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001567181,0.0001434525,0.00009856992,0.0001080647,0.00001544148,0.0000054788,0.0005819598,0.00001103553,0.9644036,0.00006273498,0.0001721478,0.03283029],"study_design_scores_gemma":[0.003911892,0.001339016,0.002030057,0.0001183902,0.0001546075,0.0005939814,0.0005220067,0.003810633,0.9865724,0.0002807529,0.0005995414,0.00006676043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993324,0.002980616,0.00009217957,0.002876367,0.0000627543,0.0005565425,0.00001368858,0.00000407099,0.00008980142],"genre_scores_gemma":[0.9984232,0.0009152258,0.0002062722,0.0002983313,0.0001435524,0.000003137382,0.000002248869,0.000003986284,0.000004060952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03276353,"threshold_uncertainty_score":0.290668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02920790178701956,"score_gpt":0.3765117536613514,"score_spread":0.3473038518743318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}