{"id":"W2119021647","doi":"10.1002/bmc.381","title":"Evaluation of 3‐hydroxy‐3‐methylglutaryl‐COA‐reductase, cholesterol‐7<i>α</i>‐hydroxylase and acyl‐COA:cholesterol acyltransferase activities: alternative chromatographic methods to separate metabolites","year":2004,"lang":"en","type":"article","venue":"Biomedical Chromatography","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Chromatography; Reductase; Sterol O-acyltransferase; Metabolite; Cholesterol; Enzyme; Acyl-CoA; High-performance liquid chromatography; Biochemistry; Lipoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007160532,0.0006271495,0.0003997274,0.0005401627,0.0001517432,0.0003653101,0.0002532464,0.0005821865,0.0006720668],"category_scores_gemma":[0.0008444762,0.0001691326,0.0002747348,0.0004460381,0.0003405658,0.0003900855,0.0001802322,0.0005242464,0.0004853762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000232427,"about_ca_system_score_gemma":0.000350863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007479844,"about_ca_topic_score_gemma":0.001268303,"domain_scores_codex":[0.9991983,0.0002358874,0.00004827241,0.0001214461,0.0003183504,0.000077803],"domain_scores_gemma":[0.9993876,0.00019612,0.00008579371,0.0000506863,0.0002186332,0.00006117282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002170144,0.00004408872,0.0007435079,0.00006395136,0.0000200871,0.00002866922,0.0000189644,0.00003552064,0.9926931,0.00003774469,0.0000161981,0.006081086],"study_design_scores_gemma":[0.000009287037,0.0004113516,0.004235968,0.000004269103,0.00003850978,0.0001800977,0.00001438344,0.0005552958,0.9937562,0.0000276349,0.0007612557,0.00000572214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8745396,0.02102603,0.09969376,0.0002171877,0.0001570281,0.0001827274,0.0006841585,0.0003109417,0.003188538],"genre_scores_gemma":[0.8969133,0.009837719,0.08500883,0.0001769327,0.0001030236,0.0002058609,0.001423876,0.00007341506,0.006256909],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.0007479844,"threshold_uncertainty_score":0.003786922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02728374895232354,"score_gpt":0.3535599651071885,"score_spread":0.326276216154865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}