{"id":"W2119032770","doi":"10.1126/science/1141515","title":"Wilms Tumor Suppressor WTX Negatively Regulates WNT/ß-Catenin Signaling","year":2007,"lang":"en","type":"article","venue":"Science","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":413,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"","keywords":"Wnt signaling pathway; Beta-catenin; Adenomatous polyposis coli; Cancer research; Biology; Xenopus; Wilms' tumor; Signal transduction; Zebrafish; Immunoprecipitation; Effector; AXIN2; Cell biology; Molecular biology; Colorectal cancer; Genetics; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007632453,0.0001226451,0.00009057276,0.00009274585,0.0002191119,0.00005280775,0.000334776,0.00006933932,0.00002693192],"category_scores_gemma":[0.0001520725,0.0001168256,0.00004880262,0.0004786107,0.0005264812,0.00001681981,0.0001165752,0.00007196009,0.00001896057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004676434,"about_ca_system_score_gemma":0.0001874506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002149017,"about_ca_topic_score_gemma":0.00002846312,"domain_scores_codex":[0.9986048,0.00001730944,0.0001962357,0.0004708479,0.0003015299,0.0004093295],"domain_scores_gemma":[0.9993654,0.00001521993,0.000103472,0.0002269586,0.0001675607,0.0001213907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003708863,0.00001183369,0.000353704,0.000003521965,0.000005392941,0.00000180076,0.00007048451,0.0007708615,0.9967874,0.00007075896,0.0001644991,0.001722656],"study_design_scores_gemma":[0.0002102937,0.00008905141,0.01277214,0.00001606898,0.000006219438,0.00002066773,0.00007394038,0.0003660562,0.9837223,0.0002334509,0.002326278,0.0001635271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962178,0.0004237135,0.001958578,0.0001251739,0.0002959871,0.0001422946,0.000003981236,0.00002319838,0.0008092461],"genre_scores_gemma":[0.9970539,0.000006754906,0.001897789,0.00009171785,0.0002249881,0.0000046187,0.00001243045,0.00001327278,0.0006945067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01306509,"threshold_uncertainty_score":0.4764012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008402240529449568,"score_gpt":0.2596561382421545,"score_spread":0.251253897712705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}