{"id":"W2119032770","doi":"10.1126/science/1141515","title":"Wilms Tumor Suppressor WTX Negatively Regulates WNT/ß-Catenin Signaling","year":2007,"lang":"en","type":"article","venue":"Science","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":413,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"","keywords":"Wnt signaling pathway; Beta-catenin; Adenomatous polyposis coli; Cancer research; Biology; Xenopus; Wilms' tumor; Signal transduction; Zebrafish; Immunoprecipitation; Effector; AXIN2; Cell biology; Molecular biology; Colorectal cancer; Genetics; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000677729,0.0005259477,0.0001623345,0.0002908904,0.000123275,0.000272111,0.0001247144,0.0001472098,0.000980747],"category_scores_gemma":[0.00009383776,0.0001100084,0.0001126608,0.0001057473,0.0002292198,0.000112373,0.0002075367,0.0002219226,0.0004443376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002805922,"about_ca_system_score_gemma":0.0001349439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003857674,"about_ca_topic_score_gemma":0.0004934825,"domain_scores_codex":[0.9999291,0.00001177264,0.000005092291,0.00001600382,0.00002620206,0.00001183682],"domain_scores_gemma":[0.9999335,0.000009427611,0.00002861236,0.000005044259,0.000005530876,0.00001791382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003715767,0.000005078151,0.0004487246,0.00001278972,0.000002348636,0.0001751174,0.000006419434,0.00007012285,0.9981021,0.000154153,0.00006802116,0.0009179942],"study_design_scores_gemma":[0.00001516141,0.00006432123,0.009967189,0.000004772138,0.00001122517,0.0009488679,0.00002115029,0.001794559,0.9826842,0.0001240422,0.004360166,0.000004393072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940975,0.001967955,0.00178742,0.0001014439,0.00002320882,0.000008250772,0.0002150031,0.0001893448,0.001609946],"genre_scores_gemma":[0.9959297,0.0007309485,0.0005501312,0.00002276436,0.000007732653,0.000006620178,0.0002086898,0.00002603539,0.00251756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000980747,"threshold_uncertainty_score":0.003280878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008402240529449568,"score_gpt":0.2596561382421545,"score_spread":0.251253897712705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}