{"id":"W2119039057","doi":"10.1021/bp000006s","title":"Increased Heterologous Protein Production in Aspergillus niger Fermentation through Extracellular Proteases Inhibition by Pelleted Growth","year":2000,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Aspergillus niger; Protease; Mycelium; Fermentation; Heterologous; Extracellular; Proteases; Biology; Aspergillus oryzae; Pellet; Food science; Spore; Biochemistry; Chemistry; Microbiology; Botany; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001724029,0.0002332574,0.0001697215,0.0001114699,0.0001213873,0.00002749865,0.0001276065,0.0005754437,0.0001013416],"category_scores_gemma":[0.00007109325,0.000240795,0.00004851632,0.00032064,0.0002816443,0.00003289359,0.00004223023,0.0002030367,0.00003512326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004544507,"about_ca_system_score_gemma":0.00003135983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000326435,"about_ca_topic_score_gemma":0.00001047047,"domain_scores_codex":[0.9983212,0.0001610587,0.0003424232,0.000711305,0.0001473282,0.0003166904],"domain_scores_gemma":[0.9993955,0.000001137121,0.0001406587,0.0003470181,0.00007825119,0.00003746538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003077896,0.000384217,0.001490958,0.00003596853,0.00001976659,0.000007121733,0.0000455913,0.000004683759,0.9880462,0.00005151288,0.0005201713,0.009085993],"study_design_scores_gemma":[0.0007662403,0.0004039711,0.001288918,0.00003504283,0.000009957311,0.0000502057,0.00004221511,0.00002048441,0.9887769,0.0001369911,0.008211739,0.0002572974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932525,0.001102447,0.0001822321,0.003719735,0.00009510079,0.001418529,0.00001708418,0.000166363,0.0000460818],"genre_scores_gemma":[0.9960639,0.0003156738,0.0006839932,0.0001341192,0.0001395324,0.0005561143,0.001148665,0.00003481486,0.000923192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008828696,"threshold_uncertainty_score":0.9819335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006258182773640418,"score_gpt":0.2212587172983036,"score_spread":0.2150005345246632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}