{"id":"W2119061990","doi":"10.1186/s12964-014-0066-6","title":"MicroRNA-188 suppresses G1/S transition by targeting multiple cyclin/CDK complexes","year":2014,"lang":"en","type":"article","venue":"Cell Communication and Signaling","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; China Postdoctoral Science Foundation; National Natural Science Foundation of China","keywords":"Nasopharyngeal carcinoma; Cyclin-dependent kinase; microRNA; Cell cycle; Cancer research; Downregulation and upregulation; Cell growth; Cyclin D1; E2F; Biology; Cyclin A; Cell cycle checkpoint; Kinase; Cell biology; Cyclin E; Cell; Gene; Medicine; Internal medicine; Genetics; Radiation therapy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002761603,0.0001227429,0.0001110441,0.00002698055,0.0002485641,0.0000539273,0.0001908427,0.000100409,0.00003358839],"category_scores_gemma":[0.00005495148,0.0001332114,0.00005071675,0.00004256617,0.00008305504,0.000009582274,0.00007478808,0.00008377525,0.000005077397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007972495,"about_ca_system_score_gemma":0.00001167623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002633854,"about_ca_topic_score_gemma":0.000007317903,"domain_scores_codex":[0.9991186,0.0002240382,0.0002286484,0.000215724,0.00007219486,0.0001408202],"domain_scores_gemma":[0.9993005,0.0000712177,0.0001118434,0.0003719097,0.00007718318,0.00006737169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002594,0.00004585296,0.0003478084,0.00003773449,0.00001014984,4.702527e-8,0.000162807,0.0003373731,0.9961281,0.00002297816,0.002445399,0.0004357918],"study_design_scores_gemma":[0.0005849766,0.00003159354,0.0002659039,0.00002661363,0.0000199495,0.000001543704,0.0001662582,0.004318592,0.9550462,0.0001157488,0.03924244,0.0001802178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.973088,0.005696299,0.0203479,0.0001956952,0.00002364204,0.0001445552,0.00002334031,0.00002611255,0.0004544891],"genre_scores_gemma":[0.9940348,0.0003769713,0.003584348,0.0002399698,0.0000558143,0.00001185731,0.001600963,0.00002092824,0.00007432591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04108196,"threshold_uncertainty_score":0.5432204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007722029848143026,"score_gpt":0.2214302070824651,"score_spread":0.2137081772343221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}