{"id":"W2119065814","doi":"10.1016/j.tiv.2006.07.013","title":"Aluminum toxicity triggers the nuclear translocation of HIF-1α and promotes anaerobiosis in hepatocytes","year":2006,"lang":"en","type":"article","venue":"Toxicology in Vitro","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"Laurentian University","funders":"University of Toronto; Industry Canada","keywords":"Hexokinase; Chromosomal translocation; Glycolysis; Lactate dehydrogenase; Metabolism; Biochemistry; Pyruvate kinase; Cytosol; Carbohydrate metabolism; Biology; Anaerobic glycolysis; Toxicity; Dehydrogenase; Glucose uptake; Anaerobic exercise; Glucose transporter; Enzyme; Chemistry; Endocrinology; Gene; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002490057,0.0001132318,0.0002117584,0.00006610319,0.00003738857,0.000006535001,0.0001226891,0.0001896975,0.00001366015],"category_scores_gemma":[0.00003196482,0.00009599811,0.00004964743,0.0001333341,0.0002214468,0.000004856082,0.00003057025,0.00009999496,9.468599e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001561567,"about_ca_system_score_gemma":0.0000471368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003957659,"about_ca_topic_score_gemma":0.001470362,"domain_scores_codex":[0.9991388,0.0001088903,0.0002511613,0.0002374739,0.00005681181,0.0002068042],"domain_scores_gemma":[0.9996704,0.00002499267,0.00007470473,0.0001825205,0.00002346725,0.00002389903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001957719,0.0001325867,0.001514577,0.00001248317,0.00001151283,6.523628e-7,0.0001415237,0.00001480712,0.9937285,0.000141512,0.0003052577,0.003800854],"study_design_scores_gemma":[0.001119887,0.0001598585,0.01801974,0.000008028713,0.00001633202,0.000008891881,0.0001175302,0.0001551424,0.9751974,0.0001915118,0.004882485,0.000123206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958088,0.002961351,0.00001892706,0.0005174451,0.0001487318,0.0002877072,0.00001641306,0.000005834969,0.0002348196],"genre_scores_gemma":[0.9985725,0.0006343626,0.000288531,0.0002077641,0.0001789906,0.00003149434,0.0000229401,0.0000121753,0.00005128192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01853107,"threshold_uncertainty_score":0.3914689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006717282177618925,"score_gpt":0.2213629223102317,"score_spread":0.2146456401326128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}