{"id":"W2119076851","doi":"10.1126/science.1202845","title":"Chromatin “Prepattern” and Histone Modifiers in a Fate Choice for Liver and Pancreas","year":2011,"lang":"en","type":"article","venue":"Science","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":199,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institute of Mental Health; National Institutes of Health","keywords":"Chromatin; Histone; Cell biology; Pancreas; Chemistry; Biology; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001352659,0.0001168963,0.0001021355,0.0001604118,0.0001390509,0.0002454235,0.0001447224,0.0001546703,0.0009989404],"category_scores_gemma":[0.0001299364,0.0001468838,0.0001171166,0.000083348,0.0003215444,0.0002160341,0.0002278216,0.0003398645,0.0002608521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001547888,"about_ca_system_score_gemma":0.0001103268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001919017,"about_ca_topic_score_gemma":0.0006333409,"domain_scores_codex":[0.9999295,0.000009358732,0.000005083724,0.00002316949,0.00002036399,0.00001238834],"domain_scores_gemma":[0.9998869,0.00002741966,0.00002408367,0.00001623034,0.00001063616,0.0000347694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004832251,0.000002798911,0.0006464507,0.000006052102,0.00000117903,0.00002559106,0.00001247679,0.00001767066,0.9982768,0.0001702561,0.000005477723,0.0007868602],"study_design_scores_gemma":[0.000007766531,0.00008958361,0.03494474,0.000003860661,0.00001111064,0.0002869685,0.00003961148,0.0005445026,0.9628627,0.0002867515,0.0009177614,0.000004550906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948444,0.0007746795,0.003240848,0.00003721491,0.000006780539,0.000006634942,0.00009272801,0.0000184382,0.0009782444],"genre_scores_gemma":[0.9968628,0.0002785173,0.001086235,0.00002678984,0.000003947257,0.000007509633,0.0001578639,0.000008964023,0.001567447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009989404,"threshold_uncertainty_score":0.003341794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03143380677194654,"score_gpt":0.2904440660582762,"score_spread":0.2590102592863296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}