{"id":"W2119076851","doi":"10.1126/science.1202845","title":"Chromatin “Prepattern” and Histone Modifiers in a Fate Choice for Liver and Pancreas","year":2011,"lang":"en","type":"article","venue":"Science","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":199,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institute of Mental Health; National Institutes of Health","keywords":"Chromatin; Histone; Cell biology; Pancreas; Chemistry; Biology; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002729789,0.00004761426,0.00004717632,0.00003465202,0.00005444617,0.00001265816,0.0000697145,0.0000311902,0.000002387215],"category_scores_gemma":[0.00009631187,0.00004472815,0.000008366079,0.00005562471,0.0002001411,0.000005853323,0.00005455604,0.00001745375,3.690675e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006633207,"about_ca_system_score_gemma":0.00002610125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001847032,"about_ca_topic_score_gemma":0.0001289147,"domain_scores_codex":[0.999524,0.00001033381,0.00006836921,0.0002253942,0.00005097062,0.0001209531],"domain_scores_gemma":[0.9997848,0.000008017825,0.00002768393,0.0001023264,0.00002832377,0.0000489067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001309232,0.00001249411,0.02946282,0.00001266951,0.000001455985,4.35172e-7,0.0003570572,0.000002375916,0.9608869,0.00005652999,0.00000577165,0.0091884],"study_design_scores_gemma":[0.0003693507,0.0001843864,0.4365819,0.00001024688,0.000004666844,0.000002021815,0.00004199941,0.00158837,0.5590196,0.0005993704,0.001476293,0.0001217401],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996065,0.001723825,0.001691939,0.00001237873,0.00003481968,0.0001106379,0.000003735773,0.000002334366,0.0003553266],"genre_scores_gemma":[0.9964696,0.0002658552,0.003106247,0.00004207122,0.00001773905,0.00001197783,0.000002521075,0.000003409919,0.00008060015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4071191,"threshold_uncertainty_score":0.1823961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03143380677194654,"score_gpt":0.2904440660582762,"score_spread":0.2590102592863296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}