{"id":"W2119080469","doi":"10.1016/s0896-6273(03)00533-6","title":"RNA-Mediated Neurodegeneration Caused by the Fragile X Premutation rCGG Repeats in Drosophila","year":2003,"lang":"en","type":"article","venue":"Neuron","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":362,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke","keywords":"Neurodegeneration; Biology; Trinucleotide repeat expansion; Drosophila melanogaster; Fragile X syndrome; Genetics; FMR1; Phenotype; Allele; Gene; Disease; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009813771,0.0001325902,0.00007264719,0.00002928628,0.00007769415,0.00002845038,0.0001114542,0.00007720044,0.00001328884],"category_scores_gemma":[0.0001269563,0.0001160113,0.00003171197,0.0001275255,0.00003342273,0.000003931913,0.0000285796,0.00009961108,0.00001313185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008796274,"about_ca_system_score_gemma":0.00003914326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001143761,"about_ca_topic_score_gemma":0.00005470355,"domain_scores_codex":[0.9989932,0.0001506406,0.0001872007,0.0003446387,0.0001338267,0.0001905629],"domain_scores_gemma":[0.9996191,0.00001311327,0.00005742934,0.0002425156,0.00002697236,0.00004082435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001228848,0.00004885942,0.001148386,0.00000330193,0.000003142927,0.000002437483,0.00004933259,0.0004507449,0.9943733,0.00001955696,0.003436943,0.0004517142],"study_design_scores_gemma":[0.001045365,0.0003027551,0.08612435,0.000004676272,0.000008661793,0.000009462626,0.0000361911,0.0003958586,0.8667395,0.0001348159,0.04492348,0.0002749479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971939,0.0002555484,0.00007292347,0.0003433526,0.0002120778,0.0002487776,0.00001003572,0.0000103905,0.001652998],"genre_scores_gemma":[0.9977487,0.0002348537,0.00002856738,0.001195662,0.0000146161,0.00003343377,0.00020468,0.00002650791,0.0005130189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1276339,"threshold_uncertainty_score":0.4730802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00844352418240084,"score_gpt":0.2176835792101557,"score_spread":0.2092400550277548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}