{"id":"W2119081353","doi":"10.1158/1078-0432.ccr-11-1122","title":"RAF265 Inhibits the Growth of Advanced Human Melanoma Tumors","year":2012,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; U.S. Public Health Service; U.S. Food and Drug Administration; Vanderbilt University Medical Center; Vanderbilt University; U.S. Department of Veterans Affairs","keywords":"Cancer research; Melanoma; MAPK/ERK pathway; Cell growth; V600E; Kinase; Cancer; Medicine; Apoptosis; Signal transduction; Mutation; Biology; Internal medicine; Gene; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001395806,0.0005156926,0.0003082593,0.0001833841,0.00012131,0.0001684914,0.0001388434,0.0001444993,0.001180753],"category_scores_gemma":[0.00007225358,0.00007863111,0.0001987487,0.00007627634,0.0001439755,0.00009529579,0.0001080373,0.0005043898,0.0003400022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001931078,"about_ca_system_score_gemma":0.0002031281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004206685,"about_ca_topic_score_gemma":0.0008089743,"domain_scores_codex":[0.9999261,0.00001286732,0.000003333658,0.00001010865,0.00002397946,0.00002364465],"domain_scores_gemma":[0.9999391,0.00001155428,0.00001313015,0.000005919118,0.000008042074,0.00002233558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001029866,0.0007610641,0.0008344194,0.00008972129,0.00001820002,0.0001139413,0.00001919186,0.0004288327,0.9867254,0.00004277048,0.0002394261,0.009697142],"study_design_scores_gemma":[0.00069627,0.03228038,0.02079021,0.00002582024,0.00008881901,0.001948943,0.00005321901,0.002917325,0.9353109,0.00006600317,0.005810856,0.00001109085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973531,0.001371601,0.000351065,0.00004900169,0.00001357376,0.00004050445,0.0001455468,0.00004858374,0.000627032],"genre_scores_gemma":[0.9971508,0.0008427766,0.0005230154,0.00002467045,0.00001316727,0.00002357376,0.0004116009,0.0000089716,0.001001358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001180753,"threshold_uncertainty_score":0.003950059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1512747835589745,"score_gpt":0.4782351862684745,"score_spread":0.3269604027095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}