{"id":"W2119130433","doi":"10.1128/aac.00117-09","title":"LFA-1 Antagonists as Agents Limiting Human Immunodeficiency Virus Type 1 Infection and Transmission and Potentiating the Effect of the Fusion Inhibitor T-20","year":2009,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada); Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Lymphocyte function-associated antigen 1; Immunology; Biology; Virology; Virus; Cell fusion; Cell adhesion; Viral replication; Enfuvirtide; Cell adhesion molecule; Cell; Antigen; Epitope; Genetics; Intercellular Adhesion Molecule-1","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001577616,0.0003546214,0.0003722237,0.000240919,0.0001534955,0.0003032985,0.0001912582,0.0001949388,0.0009492501],"category_scores_gemma":[0.0001838019,0.000133257,0.0002205553,0.0001166931,0.0001713701,0.0001868043,0.0001222697,0.0005291831,0.0002246722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001343188,"about_ca_system_score_gemma":0.0001815564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002491389,"about_ca_topic_score_gemma":0.0006066525,"domain_scores_codex":[0.9998734,0.00004061176,0.000008203953,0.00001117786,0.00002728813,0.00003929618],"domain_scores_gemma":[0.9999287,0.00002682866,0.00001390458,0.000005673799,0.000006613042,0.00001831549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001112354,0.0003739256,0.0002736796,0.0001204317,0.00004188916,0.0001774427,0.00003316883,0.0004332067,0.974705,0.0005151834,0.0003219391,0.02189162],"study_design_scores_gemma":[0.0003651377,0.01005649,0.004878363,0.000028829,0.0001703893,0.00130162,0.00003143204,0.001742588,0.96955,0.0002300337,0.01162822,0.00001704955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829758,0.01264309,0.001189737,0.0001148513,0.00006003585,0.00006190752,0.00009614658,0.00006027278,0.002798121],"genre_scores_gemma":[0.9884531,0.007660816,0.0017749,0.000105503,0.00007210093,0.00005726152,0.0002005051,0.00001540244,0.001660475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009492501,"threshold_uncertainty_score":0.003175616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008658720828176487,"score_gpt":0.2662906822778588,"score_spread":0.2576319614496823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}