{"id":"W2119189554","doi":"10.1095/biolreprod.109.081646","title":"Rescue of Postcompaction-Stage Mouse Embryo Development from Hypertonicity by Amino Acid Transporter Substrates That May Function as Organic Osmolytes1","year":2009,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian Institutes of Health Research","keywords":"Osmolyte; Biology; Blastocyst; Osmotic concentration; Osmotic shock; Embryo; Betaine; Biochemistry; Intracellular; Cell biology; Embryogenesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005499827,0.0002348347,0.000545467,0.0001106464,0.00009226702,0.000002816577,0.00009714834,0.000350724,0.0004355226],"category_scores_gemma":[0.0001818689,0.0001915108,0.0001168169,0.0001766661,0.0003154962,0.0001250415,0.00001112683,0.0002583523,0.00003422024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008168162,"about_ca_system_score_gemma":0.0001277945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002912102,"about_ca_topic_score_gemma":0.00001752048,"domain_scores_codex":[0.9979751,0.000138788,0.0005700254,0.0009423053,0.0001367211,0.0002370629],"domain_scores_gemma":[0.9985899,0.00002717477,0.0002908301,0.0007759925,0.0002434407,0.00007262491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004492358,0.0004583416,0.1369938,0.00002400135,0.0001690981,0.000001217546,0.0001667974,9.731341e-7,0.8488361,0.00002214431,0.0001825534,0.008652704],"study_design_scores_gemma":[0.0003858017,0.0005268948,0.473329,0.00001071274,0.00005109897,0.0000139401,0.00009033142,5.683188e-7,0.5235286,0.0001299404,0.001849115,0.00008397268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938616,0.003327428,0.0005617102,0.001061433,0.0004565919,0.0004265356,0.00004121804,0.00008569668,0.0001778044],"genre_scores_gemma":[0.9969833,0.0002192898,0.0006072094,0.00008655143,0.0001713965,0.000007797217,0.0006657126,0.00001268546,0.001245995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3363353,"threshold_uncertainty_score":0.7809582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02532613974806785,"score_gpt":0.26455584027305,"score_spread":0.2392297005249822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}