{"id":"W2119207863","doi":"10.1124/mol.105.017855","title":"Valproic Acid Increases Conservative Homologous Recombination Frequency and Reactive Oxygen Species Formation: A Potential Mechanism for Valproic Acid-Induced Neural Tube Defects","year":2005,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Pharmacological Effects and Toxicity Studies","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Valproic Acid; Neural tube; Catalase; Homologous recombination; Reactive oxygen species; Chemistry; DNA damage; Biochemistry; Oxidative stress; Molecular biology; Cell biology; Biology; DNA; Embryo; Epilepsy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003205997,0.0003749797,0.0006218274,0.000205282,0.0003584921,0.00003083484,0.0001340855,0.0002176221,0.0001166898],"category_scores_gemma":[0.0003773269,0.0003273384,0.000198038,0.0002216306,0.0001769789,0.0002920048,0.0001398622,0.0003794317,0.00001382998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002462068,"about_ca_system_score_gemma":0.00009160169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002825338,"about_ca_topic_score_gemma":0.00001061506,"domain_scores_codex":[0.9979067,0.0003704383,0.0004041849,0.0005331459,0.0002362494,0.0005492245],"domain_scores_gemma":[0.9987546,0.0002254898,0.0002277064,0.0001374102,0.0004276812,0.0002271466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006876119,0.0005003521,0.00008206716,0.0001279129,0.0004446733,0.000324765,0.0002328326,0.000007456552,0.9928607,0.001724329,0.000917047,0.002090298],"study_design_scores_gemma":[0.007614085,0.002750187,0.003751082,0.00002440773,0.000978885,0.0005465862,0.0001155996,0.005147456,0.9740516,0.004460788,0.0002101893,0.0003491279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833188,0.0008588931,0.003822993,0.008290758,0.0003865511,0.002609217,0.00004252262,0.0001608094,0.0005094769],"genre_scores_gemma":[0.9879344,0.0001434437,0.001517637,0.009192428,0.0003076192,0.0007046566,0.0000878573,0.00003567925,0.0000762862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01880905,"threshold_uncertainty_score":0.9999179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02596673299447454,"score_gpt":0.3025998643366533,"score_spread":0.2766331313421788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}