{"id":"W2119263822","doi":"10.1038/ncomms9760","title":"Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":507,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Centre for Applied Research in Cancer Control; BC Cancer Agency","funders":"Medical Research Council; European Commission; NIHR Cambridge Biomedical Research Centre; National Breast Cancer Foundation; Academy of Medical Sciences; National Institute for Health and Care Research; University of Cambridge; Cancer Research UK; Science Foundation Arizona","keywords":"Somatic evolution in cancer; Metastatic breast cancer; Breast cancer; Exome; Tumour heterogeneity; Exome sequencing; Amplicon; Cancer; DNA sequencing; Biology; Liquid biopsy; Biopsy; Targeted therapy; Cancer research; Pathology; Mutation; Oncology; Medicine; DNA; Gene; Polymerase chain reaction; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001798168,0.0001847104,0.0001970296,0.0007944594,0.0004276932,0.0003288826,0.0002794376,0.000607532,0.0006073111],"category_scores_gemma":[0.001482103,0.0001758874,0.0001386952,0.0003277221,0.0003310838,0.0002473166,0.000279457,0.0004872908,0.000183579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003429235,"about_ca_system_score_gemma":0.0001147481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002039059,"about_ca_topic_score_gemma":0.002419461,"domain_scores_codex":[0.9998463,0.00001924283,0.00001156924,0.00005315078,0.00003763818,0.00003201322],"domain_scores_gemma":[0.9991995,0.0003212237,0.0001821937,0.00005290678,0.00008601782,0.0001581977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.0009194317,0.0001005467,0.3144394,0.0001173282,0.00004759477,0.5123442,0.002451571,0.001517588,0.1354098,0.0006215778,0.0006784963,0.0313524],"study_design_scores_gemma":[0.00003256644,0.0004707914,0.2390221,0.00002810542,0.00006168377,0.731431,0.000449907,0.006355624,0.01927743,0.00059314,0.002246314,0.00003125397],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967715,0.0004350825,0.00162401,0.0001474476,0.000007338724,0.00001892291,0.00006218237,0.00003044519,0.0009029635],"genre_scores_gemma":[0.9988152,0.00009652351,0.0008289056,0.00004257609,0.00001123809,0.000004350359,0.00003847614,0.00000497498,0.000157819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002039059,"threshold_uncertainty_score":0.004054427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0388270027616022,"score_gpt":0.3384512625269552,"score_spread":0.299624259765353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}