{"id":"W2119289645","doi":"10.1016/j.pep.2008.03.013","title":"Recombinant proprotein convertase 4 (PC4) from Leishmania tarentolae expression system: Purification, biochemical study and inhibitor design","year":2008,"lang":"en","type":"article","venue":"Protein Expression and Purification","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Ottawa Hospital Research Institute","keywords":"Proprotein convertase; Proprotein Convertases; Subtilisin; Biochemistry; Proteolysis; Kexin; Recombinant DNA; Biology; Enzyme; Proteinase K; Peptide; Enteropeptidase; Protein precursor; Chemistry; Molecular biology; Fusion protein; Lipoprotein","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002854296,0.0002731303,0.0002263126,0.00006524508,0.0004033847,0.00006254271,0.0001822822,0.0002660105,0.00001307019],"category_scores_gemma":[0.00007870473,0.0002320388,0.00003867589,0.00007967542,0.0001270302,0.00002165013,0.0001016684,0.0001493213,0.000009337476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002282002,"about_ca_system_score_gemma":0.0000719365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006611422,"about_ca_topic_score_gemma":0.000005109507,"domain_scores_codex":[0.9979754,0.0003087678,0.0004273922,0.0007764973,0.000269478,0.0002424595],"domain_scores_gemma":[0.9988358,0.00001613058,0.0002326926,0.0005779841,0.0001692972,0.0001681069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004122248,0.000295959,0.002479886,0.00006962365,0.00001369716,0.000005534547,0.0004739736,0.000001307333,0.9935727,0.00001095163,0.00154871,0.001115503],"study_design_scores_gemma":[0.001222147,0.0003719596,0.006089654,0.0001764139,0.00001852482,0.00001506106,0.0004971196,0.00009563068,0.9888824,0.00005138465,0.00226883,0.0003109336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873818,0.003405965,0.006581096,0.00009126711,0.0001044481,0.002329676,0.00002212476,0.00004800438,0.00003566348],"genre_scores_gemma":[0.9918575,0.0002649064,0.006195752,0.00002600164,0.0001881472,0.0008138039,0.0002416575,0.00003296187,0.0003792233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004690289,"threshold_uncertainty_score":0.9462269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01698891999334998,"score_gpt":0.2272919253616462,"score_spread":0.2103030053682962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}