{"id":"W2119364523","doi":"10.1186/s12934-015-0198-4","title":"Serine protease inhibitors protect better than IL-10 and TGF-β anti-inflammatory cytokines against mouse colitis when delivered by recombinant lactococci","year":2015,"lang":"en","type":"article","venue":"Microbial Cell Factories","topic":"Probiotics and Fermented Foods","field":"Agricultural and Biological Sciences","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Conseil Régional Midi-Pyrénées; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Elafin; Lactococcus lactis; Serine protease; SLPI; Colitis; Protease; Proteases; Microbiology; Biology; Inflammation; Immunology; Lactic acid; Enzyme; Biochemistry; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002200629,0.0005682787,0.0004485738,0.0002748957,0.0000684078,0.000327065,0.000206608,0.0003388111,0.001121125],"category_scores_gemma":[0.0001917777,0.0001170196,0.0003427416,0.0001577511,0.0001863382,0.0002355402,0.0001166358,0.000768327,0.0003213311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001643336,"about_ca_system_score_gemma":0.0002140034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002815097,"about_ca_topic_score_gemma":0.0002891413,"domain_scores_codex":[0.9997805,0.00004128647,0.00003021891,0.00003805051,0.00005851075,0.00005139679],"domain_scores_gemma":[0.9997473,0.00004174448,0.000115758,0.00002358687,0.00002392629,0.00004764182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003611033,0.0001022143,0.0001377392,0.00005665498,0.00000753401,0.00002024881,0.000007015388,0.0000433552,0.9977399,0.00001909686,0.00001875572,0.001486378],"study_design_scores_gemma":[0.00002515569,0.001211465,0.0008363693,0.000006053484,0.0000164892,0.00008832831,0.000008710221,0.0001677439,0.9968264,0.000007523559,0.0008035435,0.000002160556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917931,0.00355682,0.003235388,0.0001506138,0.0000462391,0.00004431847,0.0003493056,0.0001431949,0.0006810538],"genre_scores_gemma":[0.9893101,0.001986953,0.00572015,0.00009390864,0.00003106981,0.00006834697,0.0007074694,0.00004214214,0.002039897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001121125,"threshold_uncertainty_score":0.003750563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01177646660476505,"score_gpt":0.1820380392015578,"score_spread":0.1702615725967927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}