{"id":"W2119370602","doi":"10.1158/0008-5472.can-04-3208","title":"In vitro Modeling of Human Pancreatic Duct Epithelial Cell Transformation Defines Gene Expression Changes Induced by K- ras Oncogenic Activation in Pancreatic Carcinogenesis","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Institutes of Health Research; U.S. Public Health Service; National Cancer Institute; University of Pennsylvania","keywords":"Carcinogenesis; Pancreatic Intraepithelial Neoplasia; Pancreatic cancer; Cancer research; Biology; Oncogene; Pancreatic duct; Pancreas; Neoplastic transformation; Gene expression profiling; Pathology; Gene expression; Cancer; Cell cycle; Gene; Medicine; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000132934,0.0002435896,0.0002377694,0.0002275112,0.0001463555,0.0003439688,0.0001300102,0.0001665467,0.001005661],"category_scores_gemma":[0.00008250597,0.0001615327,0.0003208744,0.0002339475,0.0002085905,0.0001294589,0.0001335586,0.0003360898,0.0005112177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002766958,"about_ca_system_score_gemma":0.0001535041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006651908,"about_ca_topic_score_gemma":0.0006028541,"domain_scores_codex":[0.9998423,0.00002711079,0.00001581168,0.00003905697,0.00003782803,0.0000378613],"domain_scores_gemma":[0.9999506,0.00001103742,0.00001188267,0.00001098037,0.000007589782,0.000007821812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005198797,0.00002707654,0.0002653634,0.00001475995,0.000001990086,0.00001871319,0.00001442173,0.0001640879,0.9989353,0.00004776083,0.00002157275,0.0004368578],"study_design_scores_gemma":[0.000003282716,0.0001601329,0.002280946,0.00000223409,0.0000089448,0.00009899798,0.00001844185,0.0009552843,0.9951208,0.00002106774,0.001327414,0.0000024196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897326,0.001248443,0.005813564,0.00006452102,0.00002817516,0.00005280465,0.0008207404,0.0001062968,0.002132831],"genre_scores_gemma":[0.9878399,0.001941745,0.006092986,0.00004401457,0.00001037073,0.0001109053,0.001971031,0.00003086534,0.001958051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001005661,"threshold_uncertainty_score":0.003364205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09212148298241804,"score_gpt":0.3901470592209111,"score_spread":0.298025576238493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}