{"id":"W2119370602","doi":"10.1158/0008-5472.can-04-3208","title":"In vitro Modeling of Human Pancreatic Duct Epithelial Cell Transformation Defines Gene Expression Changes Induced by K- ras Oncogenic Activation in Pancreatic Carcinogenesis","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Institutes of Health Research; U.S. Public Health Service; National Cancer Institute; University of Pennsylvania","keywords":"Carcinogenesis; Pancreatic Intraepithelial Neoplasia; Pancreatic cancer; Cancer research; Biology; Oncogene; Pancreatic duct; Pancreas; Neoplastic transformation; Gene expression profiling; Pathology; Gene expression; Cancer; Cell cycle; Gene; Medicine; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00171389,0.0002516093,0.0008539006,0.0008725799,0.0001622209,0.00001824768,0.0002462723,0.0002926376,0.0001580203],"category_scores_gemma":[0.0001098905,0.000224775,0.00008943553,0.0009787874,0.0001370641,0.0002819945,0.00006523776,0.0006953129,0.00001553074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009392201,"about_ca_system_score_gemma":0.0006364637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005516939,"about_ca_topic_score_gemma":0.0005203026,"domain_scores_codex":[0.9965061,0.0004023372,0.0007183968,0.000489128,0.001049109,0.0008349563],"domain_scores_gemma":[0.9986508,0.0002509346,0.0001197385,0.0004219168,0.0003492836,0.0002072975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001292562,0.0004137193,0.009568195,0.0005212839,0.00002930637,0.000006625024,0.002121903,0.0001643702,0.9842539,0.00001183485,0.0001101467,0.001506085],"study_design_scores_gemma":[0.004109475,0.0004197798,0.00224768,0.00047751,0.00006504502,0.000004607752,0.000586302,0.005911099,0.9858154,0.00009178845,0.00008594673,0.0001853438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936661,0.001626133,0.0001332971,0.001980707,0.00003433166,0.001471864,0.00003616282,0.00002228746,0.001029091],"genre_scores_gemma":[0.9957983,0.00207297,0.0004090238,0.0001412164,0.0002829217,0.0008256409,0.0001047181,0.00005060695,0.0003145952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007320515,"threshold_uncertainty_score":0.9166059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09212148298241804,"score_gpt":0.3901470592209111,"score_spread":0.298025576238493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}