{"id":"W2119397592","doi":"10.1002/iub.461","title":"Structural basis of thrombin–protease‐activated receptor interactions","year":2011,"lang":"en","type":"review","venue":"IUBMB Life","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Tellabs (Canada)","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Thrombin; Scissile bond; Protease-activated receptor; Proteases; Protease; Chemistry; Biochemistry; Receptor; Trypsin; Thrombin receptor; Active site; Cell biology; Platelet; Biophysics; Biology; Enzyme; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001394171,0.0004322189,0.002101687,0.0003185404,0.00007170687,0.0000150499,0.0001956485,0.0003571231,0.007151045],"category_scores_gemma":[0.0002430528,0.0003347821,0.0007080622,0.0004586751,0.00007369118,0.0001118697,0.00007880376,0.0005720361,0.0003881345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001025259,"about_ca_system_score_gemma":0.0004914572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008230739,"about_ca_topic_score_gemma":0.000003409948,"domain_scores_codex":[0.99799,0.0001735241,0.0008859115,0.0004185656,0.0002728478,0.0002591876],"domain_scores_gemma":[0.998027,0.00009708596,0.00070987,0.0006571807,0.0002014077,0.0003074229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008499877,0.0004518169,0.00003033639,0.01882302,0.002868213,0.000006735977,0.0002660171,1.191522e-7,0.001007023,0.007178705,0.008720066,0.9605629],"study_design_scores_gemma":[0.0006471908,0.0002231432,0.00008214141,0.01139527,0.002270299,0.00007988459,0.00004967751,0.000004352037,0.002270675,0.0001393012,0.9824479,0.0003902015],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006048874,0.9908618,0.00004056568,0.00009607377,0.001629456,0.001711146,0.0001539599,0.0001858729,0.004716288],"genre_scores_gemma":[0.003225441,0.9930287,0.00113411,0.0001738556,0.000413195,0.0001325856,0.0004307042,0.0001161804,0.001345219],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9737278,"threshold_uncertainty_score":0.9999104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1285381685785671,"score_gpt":0.3640852742035671,"score_spread":0.2355471056249999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}