{"id":"W2119424368","doi":"10.1002/anie.201412154","title":"A Potent, Selective and Cell‐Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3)","year":2015,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"National Institutes of Health; Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation; National Institute of General Medical Sciences; Ontario Genomics Institute; Ontario Genomics; Genome Canada; Wellcome Trust; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Allosteric regulation; Methyltransferase; Chemistry; Chemical biology; Biochemistry; Arginine; Enzyme; Epigenetics; Amino acid; Methylation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002324923,0.0003772696,0.0002964199,0.0002283725,0.0002269516,0.0001813019,0.0004086597,0.0004188943,0.0009264708],"category_scores_gemma":[0.0001252084,0.0001235395,0.0002461972,0.0002010304,0.0002716833,0.000145794,0.0002430961,0.0007955832,0.0005185903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003815686,"about_ca_system_score_gemma":0.0003657221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006490116,"about_ca_topic_score_gemma":0.001875685,"domain_scores_codex":[0.9998282,0.00002515513,0.000007636041,0.00002825001,0.00007796551,0.00003272473],"domain_scores_gemma":[0.9999413,0.00001142184,0.00001365332,0.00000747963,0.00001092658,0.00001509376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008453806,0.00006388263,0.0001623974,0.0001172558,0.00001227294,0.00003966249,0.00001316226,0.0003320594,0.9884643,0.0003749068,0.000513946,0.009821749],"study_design_scores_gemma":[0.00003211502,0.0004997497,0.0004327558,0.000003935387,0.00001499909,0.000176607,0.000006322321,0.0005736575,0.9901555,0.00005882201,0.008038913,0.000006688939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8928279,0.03194815,0.05085612,0.00116251,0.0002655788,0.0003894735,0.001356018,0.000999778,0.02019446],"genre_scores_gemma":[0.9704226,0.007518981,0.01507304,0.0004252316,0.00004038446,0.00009860927,0.001276855,0.00004462038,0.005099678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009264708,"threshold_uncertainty_score":0.003099322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01035828654595878,"score_gpt":0.2419209419019298,"score_spread":0.231562655355971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}