{"id":"W2119424368","doi":"10.1002/anie.201412154","title":"A Potent, Selective and Cell‐Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3)","year":2015,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"National Institutes of Health; Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation; National Institute of General Medical Sciences; Ontario Genomics Institute; Ontario Genomics; Genome Canada; Wellcome Trust; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Allosteric regulation; Methyltransferase; Chemistry; Chemical biology; Biochemistry; Arginine; Enzyme; Epigenetics; Amino acid; Methylation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001058985,0.0001204205,0.0001076218,0.00006767777,0.0000211762,0.00001224608,0.00007658653,0.0001294347,0.00001654262],"category_scores_gemma":[0.0001036919,0.0001259007,0.00005072327,0.00008684549,0.00006142438,0.00002027749,0.0000408516,0.00008017205,0.000002383319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007326737,"about_ca_system_score_gemma":0.00009152151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005391097,"about_ca_topic_score_gemma":0.00002109029,"domain_scores_codex":[0.9992098,0.000025015,0.0001828315,0.0002593439,0.0002195813,0.00010347],"domain_scores_gemma":[0.9992365,0.000008367168,0.000191623,0.0001001405,0.0003892908,0.0000740777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004299037,0.00007420228,0.0001184529,0.00001522049,0.00007409586,0.000001223606,0.000153314,0.00005084172,0.9955328,0.00001400943,0.002442162,0.001093849],"study_design_scores_gemma":[0.001257992,0.0002749832,0.0005613398,0.00003134604,0.00002350476,0.00001567047,0.0001001738,0.00005907028,0.9927593,0.0002469915,0.004542377,0.0001271782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911247,0.0004129192,0.00411991,0.0004637124,0.0004275029,0.0002944313,0.0001499554,0.00001357819,0.002993303],"genre_scores_gemma":[0.9970553,0.00007289959,0.000419792,0.00005009932,0.0009843991,0.00005659214,0.0008802764,0.00001629199,0.0004643797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005930582,"threshold_uncertainty_score":0.5134079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01035828654595878,"score_gpt":0.2419209419019298,"score_spread":0.231562655355971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}