{"id":"W2119436953","doi":"10.1007/s12010-008-8266-4","title":"Isolation and Functional Characterization of Single Domain Antibody Modulators of Caspase-3 and Apoptosis","year":2008,"lang":"en","type":"article","venue":"Applied Biochemistry and Biotechnology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Canada; Steacie Institute for Molecular Sciences; Institute for Biological Sciences; National Research Council Canada; University of Windsor","funders":"Heart and Stroke Foundation of Canada","keywords":"Apoptosis; Neurodegeneration; Programmed cell death; Caspase; Cell biology; Biology; Intrinsic apoptosis; Cancer cell; Cancer research; Cancer; Biochemistry; Disease; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004745542,0.00008886451,0.0001976878,0.00007529224,0.00006200746,0.000001909413,0.00002135352,0.0002441806,0.00001238171],"category_scores_gemma":[0.00001144743,0.00007519094,0.00001743455,0.0001268785,0.0005873955,0.00001596107,0.00006046685,0.0001006857,3.051604e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006148668,"about_ca_system_score_gemma":0.00001894289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001227696,"about_ca_topic_score_gemma":2.3013e-7,"domain_scores_codex":[0.9994401,0.000004417278,0.0001678654,0.0001896507,0.00009526419,0.0001027367],"domain_scores_gemma":[0.9997295,0.0000202016,0.000076005,0.00009178921,0.0000360146,0.00004652513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002387058,0.00007554272,0.009694363,0.0002055028,0.0000334693,0.000001692478,0.00003434208,5.29472e-8,0.9869116,0.0008398612,0.000007288944,0.001957602],"study_design_scores_gemma":[0.0004386416,0.0001444618,0.03808319,0.00002264874,0.00001622516,0.0001639736,0.000063159,0.00004310402,0.9606568,0.0001456303,0.0001579451,0.00006427857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983431,0.0001648924,0.0003208428,0.0008417045,0.00001007006,0.0001023674,0.00002649345,0.00001607335,0.0001744641],"genre_scores_gemma":[0.9983432,0.0006615015,0.0007058678,0.00002919114,0.00003062871,0.000003419632,0.0001419121,0.000004955778,0.00007936865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02838883,"threshold_uncertainty_score":0.3066197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0141120896650861,"score_gpt":0.2381082664892761,"score_spread":0.22399617682419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}