{"id":"W2119484735","doi":"10.1371/journal.pone.0013579","title":"Safety and Immunogenicity of a Replication-Defective Adenovirus Type 5 HIV Vaccine in Ad5-Seronegative Persons: A Randomized Clinical Trial (HVTN 054)","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Killam Trusts; National Institutes of Health; Vanderbilt University","keywords":"Reactogenicity; Immunogenicity; Virology; HIV vaccine; ELISPOT; Vaccination; Medicine; Immunology; Antigen; Viral vector; Antibody; Immunity; Neutralizing antibody; AIDS Vaccines; Immune system; HIV Antigens; Vaccine trial; CD8; Biology; Virus; Recombinant DNA; Viral disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003126276,0.001244556,0.0016012,0.0003433859,0.0003285198,0.0009258704,0.000753477,0.001548451,0.004172659],"category_scores_gemma":[0.002031581,0.0005053523,0.001166409,0.0002594564,0.001115744,0.0007823969,0.0003218969,0.001670879,0.0005605317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006946616,"about_ca_system_score_gemma":0.001157146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004860788,"about_ca_topic_score_gemma":0.0006412929,"domain_scores_codex":[0.9987831,0.0007318581,0.00008781823,0.0001919334,0.00007786952,0.0001274683],"domain_scores_gemma":[0.9989937,0.0002621761,0.0002807047,0.00009427805,0.0000808354,0.0002882576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9777406,0.007578254,0.001032839,0.0002624636,0.0003180466,0.00002272988,0.00003883275,0.0001496954,0.003571816,0.00006327401,0.0002252253,0.008996138],"study_design_scores_gemma":[0.8124163,0.1838006,0.001963406,0.00002491596,0.0002777482,0.00002917569,0.00001963952,0.000273884,0.0007591296,0.00008515559,0.0003418782,0.000008144187],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937941,0.001184669,0.0004477392,0.0002319303,0.0002270681,0.002988483,0.0003855464,0.00004712741,0.0006932697],"genre_scores_gemma":[0.9910761,0.0007852436,0.001449783,0.0004271768,0.0002877787,0.003885197,0.0005931726,0.00001089096,0.001484561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004172659,"threshold_uncertainty_score":0.01653355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04696785350050445,"score_gpt":0.343090484571298,"score_spread":0.2961226310707936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}