{"id":"W2119484735","doi":"10.1371/journal.pone.0013579","title":"Safety and Immunogenicity of a Replication-Defective Adenovirus Type 5 HIV Vaccine in Ad5-Seronegative Persons: A Randomized Clinical Trial (HVTN 054)","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Killam Trusts; National Institutes of Health; Vanderbilt University","keywords":"Reactogenicity; Immunogenicity; Virology; HIV vaccine; ELISPOT; Vaccination; Medicine; Immunology; Antigen; Viral vector; Antibody; Immunity; Neutralizing antibody; AIDS Vaccines; Immune system; HIV Antigens; Vaccine trial; CD8; Biology; Virus; Recombinant DNA; Viral disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002793732,0.0001551704,0.0006373212,0.0000765069,0.00005162673,0.00001073674,0.0002188874,0.0002462928,0.0001110222],"category_scores_gemma":[0.004327178,0.0001401437,0.0001410892,0.0001840719,0.0002320862,0.000005952121,0.0001306861,0.0004065518,0.00001014153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001688563,"about_ca_system_score_gemma":0.0002211243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007475719,"about_ca_topic_score_gemma":0.0004314139,"domain_scores_codex":[0.9976978,0.0007272478,0.0006161144,0.0005279746,0.0002158265,0.0002149802],"domain_scores_gemma":[0.9983147,0.0003965491,0.0002241428,0.0007263258,0.0002517355,0.00008652159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.5168018,0.0007926883,0.001306106,0.00001119475,0.0003881658,5.743142e-7,0.00008886374,4.925317e-7,0.4800707,0.00001763101,0.00001543707,0.0005063462],"study_design_scores_gemma":[0.4116149,0.004252134,0.002440122,0.00003642297,0.0001359274,0.000001978894,0.00005929736,0.0002195616,0.5807794,0.0001681129,0.00008183525,0.0002103187],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968534,0.000933895,0.00003191113,0.0002511645,0.00004186,0.001571651,0.00004260803,0.000009383463,0.0002642043],"genre_scores_gemma":[0.9972406,0.001296969,0.0007300356,0.00007553666,0.0001987425,0.0001200307,0.00006964015,0.00002483369,0.0002435982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1051869,"threshold_uncertainty_score":0.5714895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04696785350050445,"score_gpt":0.343090484571298,"score_spread":0.2961226310707936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}