{"id":"W2119502157","doi":"10.1136/gut.2005.089813","title":"Oesophageal squamous cell carcinoma may develop within a background of accumulating DNA methylation in normal and dysplastic mucosa","year":2006,"lang":"en","type":"article","venue":"Gut","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Methylation; DNA methylation; Epithelium; CpG site; Biology; Epigenetics; Precancerous condition; Cancer research; Pathology; Cancer; Intraepithelial neoplasia; Carcinoma; Medicine; DNA; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001832129,0.0002024122,0.0002262637,0.0004837031,0.0001814518,0.0001679756,0.00009924193,0.0001840337,0.0009452277],"category_scores_gemma":[0.0005468691,0.0001299996,0.0001231537,0.0002843192,0.0002284777,0.0001444867,0.000233614,0.0001261067,0.000152775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001828121,"about_ca_system_score_gemma":0.0001074781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004885305,"about_ca_topic_score_gemma":0.0005532214,"domain_scores_codex":[0.9998821,0.00002097946,0.00001471081,0.00002755648,0.00003103001,0.00002369423],"domain_scores_gemma":[0.9998091,0.00003721039,0.0000744995,0.00001758387,0.00002533681,0.00003625871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001322125,0.00005966663,0.7872978,0.0002038736,0.000115731,0.003104532,0.0003972352,0.0001753987,0.1884458,0.0001328611,0.00009027858,0.0186545],"study_design_scores_gemma":[0.00001847818,0.0006986986,0.966362,0.00001670554,0.000113656,0.01298798,0.0002298733,0.0002372395,0.01796873,0.0001423785,0.001217996,0.000006382843],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990215,0.0005653274,0.0001245683,0.00000702525,0.000001324752,0.000004661314,0.00003059623,0.000004244045,0.000240688],"genre_scores_gemma":[0.9995659,0.0001748241,0.0001053011,0.000004669871,0.000002552692,0.000002804712,0.0000585597,0.000001095823,0.00008437069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009452277,"threshold_uncertainty_score":0.003162146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02774843860065023,"score_gpt":0.3017043854147031,"score_spread":0.2739559468140528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}