{"id":"W2119502157","doi":"10.1136/gut.2005.089813","title":"Oesophageal squamous cell carcinoma may develop within a background of accumulating DNA methylation in normal and dysplastic mucosa","year":2006,"lang":"en","type":"article","venue":"Gut","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Methylation; DNA methylation; Epithelium; CpG site; Biology; Epigenetics; Precancerous condition; Cancer research; Pathology; Cancer; Intraepithelial neoplasia; Carcinoma; Medicine; DNA; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002306754,0.0001316193,0.0002395002,0.0001634003,0.00004581684,0.00001458224,0.00004071955,0.00006468343,0.0000516115],"category_scores_gemma":[0.0000462323,0.0001130719,0.00002768687,0.0002694725,0.00005363607,0.00009776914,0.00004282794,0.0001502693,0.00001217731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000148003,"about_ca_system_score_gemma":0.000192423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001757031,"about_ca_topic_score_gemma":0.0007178215,"domain_scores_codex":[0.9988527,0.00005664527,0.0003240303,0.0002170105,0.0002820129,0.0002675824],"domain_scores_gemma":[0.9994421,0.0001641927,0.00009023993,0.0001289628,0.00007796838,0.00009652792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004440636,0.0003023114,0.9878334,0.0004615461,0.00001511773,0.0006689894,0.0005899715,0.0003014923,0.007200213,0.0004159389,0.00005028677,0.001716681],"study_design_scores_gemma":[0.003788362,0.0004964257,0.9608033,0.00003198878,0.00003761687,0.00003561058,0.0001446146,0.001633982,0.03279373,0.0001423274,0.000007254067,0.00008483975],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957802,0.001921458,0.000105008,0.00005434316,0.0000357893,0.0003230288,0.00001008129,0.00001536339,0.001754708],"genre_scores_gemma":[0.9974005,0.000002993142,0.002073186,0.00002220787,0.00007400826,0.00002003055,0.00005051726,0.00001624351,0.0003403524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02703014,"threshold_uncertainty_score":0.4610939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02774843860065023,"score_gpt":0.3017043854147031,"score_spread":0.2739559468140528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}