{"id":"W2119550206","doi":"10.1002/anie.201309464","title":"Polyethylene Glycol Backfilling Mitigates the Negative Impact of the Protein Corona on Nanoparticle Cell Targeting","year":2014,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":369,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Polyethylene glycol; PEG ratio; Nanoparticle; Ligand (biochemistry); Biophysics; Linker; Receptor; Corona (planetary geology); Chemistry; Molecule; Cell; Cell biology; Nanotechnology; Materials science; Biochemistry; Biology; Organic chemistry; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001300266,0.0004344151,0.0002752568,0.0001301142,0.0001144311,0.0003562582,0.0002197339,0.0003907515,0.0007548598],"category_scores_gemma":[0.0002414935,0.0001714002,0.000185893,0.000105863,0.0002231281,0.0003189837,0.0002460524,0.0003580593,0.0002702217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001866095,"about_ca_system_score_gemma":0.0002630552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005226593,"about_ca_topic_score_gemma":0.0005671697,"domain_scores_codex":[0.9998915,0.00001569336,0.000008825385,0.00002223654,0.00003429524,0.00002743948],"domain_scores_gemma":[0.9998828,0.00002844192,0.0000389759,0.00001664851,0.00001778531,0.00001530486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006926973,0.00001581579,0.00005339229,0.00002957716,0.000002730044,0.00005865372,0.00001896614,0.0001089389,0.9973683,0.0001079736,0.00004563881,0.002120792],"study_design_scores_gemma":[0.00000392763,0.00009149173,0.0002282357,0.000002525305,0.000004892506,0.00008262917,0.000004890127,0.0003571659,0.9979443,0.00002176521,0.001255937,0.000002230483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864982,0.001255531,0.008992067,0.0002308111,0.00005397491,0.00004172708,0.00009770379,0.000360858,0.002469174],"genre_scores_gemma":[0.9912797,0.0007653563,0.004766278,0.0001332749,0.00001172832,0.00002415374,0.0001049815,0.00007196631,0.00284263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007548598,"threshold_uncertainty_score":0.00252527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00928671330079043,"score_gpt":0.2391693038828047,"score_spread":0.2298825905820143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}