{"id":"W2119564057","doi":"10.1161/01.res.0000179535.06458.f8","title":"Kv1.5 Surface Expression Is Modulated by Retrograde Trafficking of Newly Endocytosed Channels by the Dynein Motor","year":2005,"lang":"en","type":"article","venue":"Circulation Research","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of British Columbia and Yukon; Heart and Stroke Foundation of Canada","keywords":"Cell biology; Dynein; Dynactin; HEK 293 cells; Endocytosis; Microtubule; Myocyte; Internalization; Dynamin; Potassium channel; Motor protein; Biology; Endosome; Cytoskeleton; Biophysics; Cell culture; Cell; Intracellular; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001470978,0.0002175809,0.0002513617,0.0001085703,0.0001614816,0.0005350033,0.0001991818,0.0002216806,0.0005104652],"category_scores_gemma":[0.0001375312,0.0001167665,0.0002702657,0.00006948373,0.0002195703,0.0003911525,0.0002035298,0.000434965,0.0002221953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004407161,"about_ca_system_score_gemma":0.0001584543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006333901,"about_ca_topic_score_gemma":0.0008451605,"domain_scores_codex":[0.9998456,0.00002079829,0.00001876147,0.00003360016,0.00003274822,0.00004849737],"domain_scores_gemma":[0.999915,0.00001949837,0.00002601368,0.000008495159,0.00001822248,0.00001277423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005229437,0.000006180353,0.0002836948,0.000025473,0.000002629367,0.00003790206,0.0000204883,0.00003957982,0.9988551,0.00008819775,0.000007885961,0.0005805453],"study_design_scores_gemma":[0.00001104063,0.0001483729,0.01349107,0.00001263416,0.00002745476,0.0002433655,0.00009211135,0.001303788,0.9833054,0.00005750707,0.001300597,0.000006628192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966159,0.001151877,0.001702439,0.00004773158,0.000009238304,0.000005200433,0.00004876574,0.00002214097,0.0003967075],"genre_scores_gemma":[0.9961648,0.00126662,0.001492211,0.00003050778,0.000005609727,0.00001110167,0.0001762362,0.00001915168,0.0008337472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006333901,"threshold_uncertainty_score":0.00319761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03956012129689022,"score_gpt":0.3214910473777408,"score_spread":0.2819309260808506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}