{"id":"W2119564057","doi":"10.1161/01.res.0000179535.06458.f8","title":"Kv1.5 Surface Expression Is Modulated by Retrograde Trafficking of Newly Endocytosed Channels by the Dynein Motor","year":2005,"lang":"en","type":"article","venue":"Circulation Research","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of British Columbia and Yukon; Heart and Stroke Foundation of Canada","keywords":"Cell biology; Dynein; Dynactin; HEK 293 cells; Endocytosis; Microtubule; Myocyte; Internalization; Dynamin; Potassium channel; Motor protein; Biology; Endosome; Cytoskeleton; Biophysics; Cell culture; Cell; Intracellular; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007084996,0.0001305169,0.0001251213,0.00007585192,0.0002605725,0.00005422197,0.0002105966,0.0002163493,0.0001411344],"category_scores_gemma":[0.0001135389,0.0001079952,0.00009554983,0.0003277733,0.0001296503,0.00001713997,0.00006231209,0.000184796,0.00001706105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004690828,"about_ca_system_score_gemma":0.00004819619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004098089,"about_ca_topic_score_gemma":0.000002569488,"domain_scores_codex":[0.9981611,0.0002765799,0.000299611,0.00036559,0.0005738842,0.0003232546],"domain_scores_gemma":[0.9990585,0.0000453539,0.0001077898,0.0003699684,0.000327653,0.0000907333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008827284,0.00006946467,0.0005394814,0.00001093158,0.00001805166,1.428155e-7,0.0001999893,0.01651612,0.9452348,0.00001122966,0.0339531,0.003358465],"study_design_scores_gemma":[0.000829743,0.0001251625,0.001340101,0.0000210297,0.000004820268,0.000003292141,0.0001931132,0.09974272,0.8616824,0.00002536083,0.03589023,0.0001420479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915257,0.0008849141,0.005160874,0.0015218,0.0001497261,0.0004332083,0.000035508,0.00002237309,0.0002659749],"genre_scores_gemma":[0.9966426,0.00008183375,0.00008540182,0.0001168519,0.0003111759,0.00001880286,0.0003976188,0.00002605706,0.002319693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08355237,"threshold_uncertainty_score":0.4403917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03956012129689022,"score_gpt":0.3214910473777408,"score_spread":0.2819309260808506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}