{"id":"W2119569986","doi":"10.1002/hep.23640","title":"Tissue Macrophages Suppress Viral Replication and Prevent Severe Immunopathology in an Interferon-I-Dependent Manner in Mice","year":2010,"lang":"en","type":"article","venue":"Hepatology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Immunopathology; Immunology; Interferon; Virology; Viral replication; Replication (statistics); Macrophage; Viral disease; Interferon alfa; Biology; Medicine; Human immunodeficiency virus (HIV); Alpha interferon; Virus; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000544115,0.00162944,0.0006301389,0.0008472493,0.0003573111,0.0004869488,0.0005206458,0.0009888912,0.001451557],"category_scores_gemma":[0.0002357242,0.0004310351,0.0004896891,0.0001596098,0.0007112151,0.000488728,0.0003476822,0.001429136,0.0009591796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004136444,"about_ca_system_score_gemma":0.0003533902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003142815,"about_ca_topic_score_gemma":0.0004460857,"domain_scores_codex":[0.9995064,0.00008929268,0.00003735345,0.00008630048,0.00007432532,0.0002064484],"domain_scores_gemma":[0.9994973,0.00005753988,0.0001813992,0.00006790888,0.00004623495,0.0001496918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008638616,0.0004359816,0.0003536634,0.00008333235,0.00001379016,0.0001279597,0.00004425199,0.0001065143,0.9944306,0.0002016028,0.000122807,0.003215587],"study_design_scores_gemma":[0.0005126973,0.004972985,0.00422525,0.00005342479,0.00005890159,0.0006644123,0.00006527664,0.0009183438,0.9848409,0.0002264763,0.003446042,0.00001522348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869472,0.00383374,0.004787365,0.000349783,0.0001077078,0.0001829877,0.0005340287,0.0006632633,0.002594052],"genre_scores_gemma":[0.9856425,0.001714048,0.004641897,0.0003047032,0.00006326973,0.0003061117,0.0006389186,0.0001489532,0.006539632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00162944,"threshold_uncertainty_score":0.004855931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008118754546808084,"score_gpt":0.2734602279906313,"score_spread":0.2653414734438232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}