{"id":"W2119585663","doi":"10.1124/jpet.105.087932","title":"DAF-FM (4-Amino-5-methylamino-2′,7′-difluorofluorescein) Diacetate Detects Impairment of Agonist-Stimulated Nitric Oxide Synthesis by Elevated Glucose in Human Vascular Endothelial Cells: Reversal by Vitamin C and l-Sepiapterin","year":2005,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Internal medicine; Endocrinology; Nitric oxide; Agonist; Chemistry; Calcium; Glucose transporter; Superoxide; Endothelial dysfunction; Histamine; Biochemistry; Biology; Insulin; Receptor; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006998996,0.0003735804,0.0008683282,0.0003364226,0.0001004375,0.00001845936,0.0001546235,0.0002294677,0.0001138227],"category_scores_gemma":[0.00002090969,0.0003222698,0.0001793826,0.0002030996,0.0002811752,0.0001721681,0.00006988357,0.0004929706,0.000003232998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002260099,"about_ca_system_score_gemma":0.00006418041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004932994,"about_ca_topic_score_gemma":9.145353e-7,"domain_scores_codex":[0.9976493,0.0003896212,0.0008953124,0.0002926066,0.0003257959,0.0004474141],"domain_scores_gemma":[0.9986929,0.0004087742,0.0004565096,0.0001383699,0.00007930473,0.000224164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002078966,0.001485157,0.001594209,0.00009499767,0.0007385909,0.0001070792,0.0005179744,0.00002695649,0.9887275,0.000001651403,0.0004525481,0.004174441],"study_design_scores_gemma":[0.01127108,0.001700991,0.001049811,0.00007536212,0.0006875899,0.0001760476,0.0002743296,0.00076378,0.9813465,0.00000847322,0.002380688,0.0002653672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828134,0.01630033,0.00004414663,0.0001612275,0.000140138,0.0004613613,0.00004138695,0.00001824707,0.00001974681],"genre_scores_gemma":[0.9942207,0.003924344,0.000815691,0.0007693527,0.000122415,0.00001526297,0.000006432837,0.00004811196,0.00007764826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01237599,"threshold_uncertainty_score":0.9999229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01079119396772851,"score_gpt":0.2927983139084287,"score_spread":0.2820071199407002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}