{"id":"W2119590603","doi":"10.1124/dmd.109.030791","title":"Breast Cancer Resistance Protein (BCRP)-Mediated Glyburide Transport: Effect of the C421A/Q141K BCRP Single-Nucleotide Polymorphism","year":2010,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Abcg2; Single-nucleotide polymorphism; Biology; Placenta; HEK 293 cells; ATP-binding cassette transporter; Pharmacology; Endocrinology; Internal medicine; Chemistry; Receptor; Gene; Biochemistry; Medicine; Genetics; Transporter; Fetus; Genotype; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003844106,0.0003499869,0.0006356457,0.0001043422,0.0003260726,0.00003432882,0.0001747968,0.0001728796,0.0001090215],"category_scores_gemma":[0.00001541106,0.0002228018,0.0002630545,0.0003890833,0.000302754,0.0001926652,0.00001746879,0.0004306195,0.000005582547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000223418,"about_ca_system_score_gemma":0.00009101971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004112971,"about_ca_topic_score_gemma":0.001177611,"domain_scores_codex":[0.9980732,0.00009226614,0.0004751436,0.0004397554,0.0005295544,0.0003900383],"domain_scores_gemma":[0.9988819,0.00004748403,0.0002343157,0.0004849207,0.0001200327,0.0002313422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002000023,0.0002210331,0.006298534,0.0005726503,0.00008633845,0.00003320153,0.0004144952,0.000001207131,0.9859818,0.001309054,0.0001349729,0.002946757],"study_design_scores_gemma":[0.004073161,0.00005166307,0.4331172,0.0008084037,0.0009877173,0.00004671097,0.00006124243,0.00001761982,0.5551807,0.0003138609,0.004973661,0.0003679918],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916751,0.002224533,0.00007353404,0.002554837,0.0008703572,0.00115913,0.000451708,0.00008768189,0.0009030651],"genre_scores_gemma":[0.9965766,0.0001330553,0.0001723952,0.0001879565,0.000420594,0.0001186521,0.000123635,0.0000531011,0.002213981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.430801,"threshold_uncertainty_score":0.9085593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002978452113195436,"score_gpt":0.201204382861408,"score_spread":0.1982259307482126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}