{"id":"W2119590603","doi":"10.1124/dmd.109.030791","title":"Breast Cancer Resistance Protein (BCRP)-Mediated Glyburide Transport: Effect of the C421A/Q141K BCRP Single-Nucleotide Polymorphism","year":2010,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Abcg2; Single-nucleotide polymorphism; Biology; Placenta; HEK 293 cells; ATP-binding cassette transporter; Pharmacology; Endocrinology; Internal medicine; Chemistry; Receptor; Gene; Biochemistry; Medicine; Genetics; Transporter; Fetus; Genotype; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005324122,0.001147755,0.0009800801,0.0005582735,0.0005638599,0.0005802131,0.0005904588,0.001311569,0.005717118],"category_scores_gemma":[0.0009957236,0.0004815381,0.0008082291,0.0005253878,0.0007975951,0.0003619001,0.0004258519,0.001221193,0.000566721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005236232,"about_ca_system_score_gemma":0.0004387121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003630356,"about_ca_topic_score_gemma":0.001905278,"domain_scores_codex":[0.9993753,0.0002367481,0.00005185639,0.0001457728,0.00007649894,0.0001139693],"domain_scores_gemma":[0.9993485,0.0002849959,0.0001358896,0.00005180576,0.0000407286,0.0001380074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.06438041,0.00190012,0.03737719,0.000118539,0.001190759,0.008505716,0.0004952141,0.001445996,0.8711528,0.001408694,0.001211526,0.01081304],"study_design_scores_gemma":[0.008255432,0.01455759,0.6692627,0.00009437738,0.003922882,0.03112672,0.0006438093,0.02253472,0.2396829,0.002156103,0.007444358,0.0003182965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984907,0.0001367148,0.0003303367,0.0002213791,0.00002313809,0.00001511983,0.0002940932,0.00001893309,0.0004695804],"genre_scores_gemma":[0.9983214,0.00008583198,0.0003027721,0.00007865501,0.00002876338,0.00001301731,0.0001818928,0.00004721775,0.0009403651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005717118,"threshold_uncertainty_score":0.0191257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002978452113195436,"score_gpt":0.201204382861408,"score_spread":0.1982259307482126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}