{"id":"W2119621449","doi":"10.1016/j.canlet.2014.01.031","title":"PKM2 contributes to cancer metabolism","year":2014,"lang":"en","type":"review","venue":"Cancer Letters","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":361,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Joseph’s Healthcare Hamilton; St. Joseph's Hospital; McMaster University; Hamilton Health Sciences","funders":"Canadian Institutes of Health Research","keywords":"PKM2; Anaerobic glycolysis; Glycolysis; Biochemistry; Chemistry; Metabolism; Oxidative phosphorylation; Carcinogenesis; Tetramer; Flux (metallurgy); Dimer; Cell biology; Biology; Pyruvate kinase; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002238455,0.0007113038,0.00193815,0.0001846783,0.0001070524,0.00007734905,0.0006999535,0.0004619425,0.0001175395],"category_scores_gemma":[0.00006918593,0.0006231904,0.0007855672,0.0003194209,0.0001209161,0.000004451518,0.0002255137,0.0003301074,0.00009469291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001329991,"about_ca_system_score_gemma":0.0005590152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002760722,"about_ca_topic_score_gemma":0.0002309908,"domain_scores_codex":[0.9972786,0.0001570235,0.0005865082,0.001021809,0.00022651,0.0007295892],"domain_scores_gemma":[0.9983898,0.00002628446,0.0003212667,0.0008663718,0.0001176324,0.0002786855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001756615,0.00001009123,0.000002384671,0.00162663,0.0005448044,9.409663e-7,0.00001268904,0.00001993266,0.00408166,0.00003867715,0.3609146,0.6327301],"study_design_scores_gemma":[0.0004305034,0.00001489728,0.00001294968,0.001808361,0.00129894,0.000005375361,0.000001959448,3.703991e-7,0.0009039699,0.000003193273,0.9947963,0.00072315],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009591952,0.9865161,0.000731816,0.00116923,0.009739039,0.000947017,0.0005792711,0.00003381456,0.0001878238],"genre_scores_gemma":[0.000008317265,0.9664881,0.00009172515,0.01468218,0.01428893,0.001934416,0.0002759759,0.0001497364,0.002080654],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6338817,"threshold_uncertainty_score":0.9996219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02029315429545397,"score_gpt":0.3264027960120235,"score_spread":0.3061096417165696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}